vonoprazan brands

Molecular formula: C17H16FN3O2S

Vonoprazan is a potassium-competitive acid blocker (PCAB) that inhibits the H⁺, K⁺-ATPase enzyme system in a potassium-competitive manner. Through this mechanism, vonoprazan suppresses basal and stimulated gastric acid secretion at the secretory surface of gastric parietal cells. Although both classes of drugs inhibit the H⁺, K⁺-ATPase, the mechanism of action of PCABs differs from that of proton-pump inhibitors (PPIs). PPIs form a covalent disulphide bond with a cysteine residue on the H⁺, K⁺-ATPase, which leads to the inactivation of the enzyme, while PCABs interfere with the binding of K⁺ to the H⁺, K⁺-ATPase.

Source: PubChem (NCBI) · compound 15981397