clobazam brands
4 registered brands containing clobazam in South Africa.
Clobazam
PubChem CID 2789Molecular formula: C16H13ClN2O2
The exact mechanism of action for clobazam, a 1,5-benzodiazepine, is not fully understood but is thought to involve the potentiation of GABAergic neurotransmission resulting from binding at the benzodiazepine site of the GABA<sub>A</sub> receptor. Specifically, clobazam binds to the interface of the α<sub>2</sub> and γ<sub>2</sub>-subunit of the GABA<sub>A</sub> receptor. It has a great affinity for the α<sub>2</sub> subunit than the α<sub>1</sub> subunit compared to other 1,4‐benzodiazepines.Binding of clobazam to the GABA<sub>A</sub> receptor causes chloride channels to open, resulting in an influx of chloride and thus hyperpolarization of neurons.
Source: PubChem (NCBI) · compound 2789
| Product | Manufacturer | Status | Country |
|---|---|---|---|
| MAZACLO 10 | - | Registered | South Africa |
| MAZACLO 20 | - | Registered | South Africa |
| URLOSAM 10 | - | Registered | South Africa |
| URLOSAM 20 | - | Registered | South Africa |