Drug Interactions Database

6278 interactions from BNF 85 - Check your medicines

Source: BNF 85

Severity: All 6278 Severe 944 Moderate 1418 Unknown 3916

selpercatinib sirolimus

increases exposure

Unknown Study

selpercatinib temsirolimus

increases exposure

Unknown Study

sevelamermodestly roxadustat

decreases exposure

Unknown Study

sevoflurane amfetamines

additive effect

Unknown Theoretical

sevoflurane sympathomimetics

additive effect

Unknown Theoretical

sirolimus mifamurtide

decreases efficacy

Unknown Theoretical

sirolimus tacrolimusandtacrolimusincreasestheexposuretosirolimus

decreases concentration

Unknown Study

snris metoprolol

increases exposure

Unknown Study

snris ozanimod

increases risk of adverseeffects

Unknown Theoretical

sodiumbicarbonate lithium

decreases concentration

Unknown Anecdotal

sofosbuvir amiodarone

increases risk of severebradycardiaorheartblock

Unknown Anecdotal

sofosbuvir antiarrhythmics

increases risk of severebradycardiaorheartblock

Unknown Anecdotal

somatrogon antiepileptics

decreases exposure

Unknown Theoretical

somatrogon carbamazepine

decreases exposure

Unknown Theoretical

somatrogon ciclosporin

decreases exposure

Unknown Theoretical

somatrogon testosterone

decreases concentration

Unknown Theoretical

sorafenib coumarins

increases anticoagulant effect

Unknown Anecdotal

sorafenib phenindione

increases risk of bleedingevents

Unknown Theoretical

sorafenib theactivecomponentofsacituzumabgovitecan

increases exposure

Unknown Theoretical

sotorasib antihistamines,non-sedating

increases exposure

Unknown Study

sotorasib benzodiazepines

decreases exposure

Unknown Study

sotorasib midazolam

decreases exposure

Unknown Study

spironolactone lithium

increases concentration

Unknown Study

spironolactone mitotane

decreases effects

Unknown Anecdotal

ssris anagrelide

increases exposure

Unknown Theoretical

ssris chlorpromazine

increases exposure

Unknown Theoretical

ssris eltrombopag

increases exposure

Unknown Theoretical

ssris fedratinib

increases exposure

Unknown Theoretical

ssris lomitapide

increases exposure

Unknown Theoretical

ssris pentoxifylline

increases exposure

Unknown Theoretical

ssris riluzole

increases exposure

Unknown Theoretical

ssris roflumilast

increases exposure

Unknown Study

ssris zolmitriptan

increases exposure

Unknown Theoretical

ssrisgivenwithamoderatecyp3a4 inhibitor tofacitinib

increases exposure

Unknown Study

statins daptomycin

increases risk of rhabdomyolysis

Unknown Theoretical

statins daptomycin

increases risk of rhabdomyolysise

Unknown Theoretical

stiripentol benzodiazepines

increases concentration

Unknown Study

stiripentol clobazam

increases concentration

Unknown Study

stiripentol(givenwithclobazam,andwithorwithout valproate)modestly fenfluramine

increases exposure

Unknown Study

stjohn’swort afatinib

decreases exposure

Unknown Study

stjohn’swort aliskiren

decreases exposure

Unknown Study

stjohn’swort alprazolam

decreases exposure

Unknown Study

stjohn’swort aminophylline

decreases concentration

Unknown Theoretical

stjohn’swort anti-androgens

decreases efficacy

Unknown Study

stjohn’swort antiepileptics

decreases exposure

Unknown Theoretical

stjohn’swort atorvastatin

decreases exposure

Unknown Study

stjohn’swort avacopan

decreases exposure

Unknown Theoretical

stjohn’swort benzodiazepines

decreases exposure

Unknown Study

stjohn’swort brivaracetam

decreases exposure

Unknown Theoretical

stjohn’swort cabozantinib

decreases exposure

Unknown Study

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6278 interactions

Important: This database uses data from the British National Formulary (BNF 85). It is for informational purposes only and is not a substitute for professional medical advice.