What it does
Abiraterone is a medication used primarily to treat prostate cancer by lowering hormone levels that fuel cancer growth.
Commonly used for: prostate cancer, hormone-sensitive prostate cancer
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:11:29 · updated 2026-08-03 04:11:41
About this medicine
Abiraterone is a medication used primarily to treat prostate cancer by lowering hormone levels that fuel cancer growth.
What it treats
- prostate cancer
- hormone-sensitive prostate cancer
How it works
It works by reducing the production of testosterone, a hormone that can help some prostate cancers grow.
Who it's for
This medicine is for men with prostate cancer, particularly those whose cancer has spread or returned after other treatments.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: abireterone
Abiraterone is an anti-androgen medication primarily used in the treatment of prostate cancer. It works by inhibiting the production of androgens, such as testosterone, which can stimulate the growth of prostate cancer cells. Abiraterone is typically used in combination with prednisone to enhance its efficacy and manage adrenal effects.
Indications
- Metastatic castration-resistant prostate cancer
- Metastatic hormone-sensitive prostate cancer
Dosage
Children: Safety and efficacy in paediatric populations have not been established; refer to specialist guidelines for any consideration.
Adults: Refer to specific prescribing guidelines for adult dosage as it may vary depending on the clinical context and concurrent medications.
Mechanism of action
Abiraterone selectively inhibits the enzyme CYP17A1, which is crucial in the biosynthesis of androgens. By blocking this enzyme, abiraterone reduces the levels of circulating testosterone and other androgens, leading to decreased stimulation of androgen receptors on prostate cancer cells and subsequently inhibiting tumor growth.
Pharmacodynamics
Abiraterone exhibits its pharmacodynamic effects by significantly lowering serum testosterone levels, which contributes to the suppression of androgen-mediated growth in prostate cancer. The use of abiraterone in combination with prednisone helps mitigate the side effects related to adrenal insufficiency that may result from androgen suppression.
Pharmacokinetics
Abiraterone is administered orally and is highly protein-bound, primarily to albumin and alpha-1 acid glycoprotein. It undergoes extensive hepatic metabolism, mainly via CYP2D6 and CYP3A4. The elimination half-life is approximately 12 hours, with the majority of the drug being excreted in the feces. Food can affect the absorption of abiraterone, so it is recommended to take it on an empty stomach.
Contra-indications
- Hypersensitivity to abiraterone or any of its components
- Severe hepatic impairment
- Pregnancy
Adverse effects
- Hypertension
- Hypokalemia
- Liver function abnormalities
- Fatigue
- Joint pain
- Hot flashes
- Nausea
- Diarrhea
Interactions
- CYP17 inhibitors may increase the risk of toxicity
- CYP3A4 inducers may decrease the effectiveness of abiraterone
- Corticosteroids may increase the risk of adverse effects
Precautions
- Monitor blood pressure regularly during treatment
- Assess liver function before and during treatment
- Use caution in patients with a history of cardiovascular disease
Pregnancy
Abiraterone is contraindicated in pregnancy due to potential harm to the fetus.
Breast-feeding
It is unknown whether abiraterone is excreted in human milk; breastfeeding is not recommended during treatment.
Storage
Store at room temperature, away from moisture and heat.
Formulations
- Tablets: 250 mg
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.