International reference: 3 US FDA recalls for this ingredient
Subpotent Drug: Formulated amount of sennosides component is less than labelled claim. (component)
Chemical Contamination: The product may contain trace amounts of benzophenone, a component of the label varnish that may leach through the bottle and into the drug product. (component)
Lack of Assurance of Sterility: Potential presence of leaks originating from the Luer component. (component)
US-market enforcement records (OpenFDA), shown for reference - not specific to this product in Zimbabwe.
ACID COMPONENT HAEMODIALYSIS CONCENTRATE
ACID COMPONENT HAEMODIALYSIS CONCENTRATE
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Sourcing - Kenya onlyRegistration & product details
Source: Medicines Control Authority of Zimbabwe · fetched 2026-04-18 08:22:04 · updated 2026-07-12 04:30:03
About component
This medicine is used to treat various health conditions.
How it works
This medicine works by having a specific effect on the body to help improve health.
Who it's for
This medicine is suitable for people with certain health conditions as prescribed by a healthcare professional.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About haemodialysis
Haemodialysis is a medical procedure that helps remove waste products and excess fluid from the blood when the kidneys are not working properly.
What it treats
- kidney failure (renal failure)
- severe kidney disease
How it works
During haemodialysis, a machine filters your blood to remove harmful substances and extra fluids, helping to keep your body in balance.
Who it's for
It is for people with kidney problems who cannot filter their blood effectively on their own.
Cautions
- • This procedure needs to be performed by trained healthcare professionals.
- • It may not be suitable for everyone, depending on individual health conditions.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: component
Component is a term often used to refer to a part of a combination product, such as a drug that is part of a multi-ingredient formulation. The specific pharmacological profile, uses, and properties of a component can vary significantly depending on the context of its use and the other ingredients it is combined with. Generally, components can act through various mechanisms, including receptor interaction, enzyme inhibition, or modulation of physiological pathways.
Dosage
Children: Refer to the BNF for Children for appropriate dosing information.
Adults: Refer to specific product guidelines and the BNF for appropriate dosing information.
Mechanism of action
The mechanism of action for a component depends on its individual pharmacological characteristics. Components may act as agonists or antagonists at specific receptors, inhibit or enhance enzyme activity, or modulate neurotransmitter levels. For example, some components may increase the availability of a neurotransmitter at synapses, thereby enhancing or inhibiting certain physiological responses.
Pharmacodynamics
Pharmacodynamics of a component involves the study of its effects on the body, including its therapeutic effects, side effects, and the relationship between drug concentration and effect. The efficacy of a component can be influenced by the presence of other ingredients in a formulation, as well as by individual patient factors such as age, weight, and genetic makeup. The therapeutic window of components can vary, necessitating careful monitoring to avoid toxicity.
Pharmacokinetics
Pharmacokinetics refers to the absorption, distribution, metabolism, and excretion (ADME) of a component. The bioavailability of a component can be affected by its formulation, route of administration, and the presence of food. Components may be metabolized in the liver or other tissues, and their elimination can occur via the kidneys or other pathways. The half-life and clearance rates of components are essential for determining dosing intervals and potential accumulation in the body.
Pregnancy
Consult a healthcare provider as safety in pregnancy varies with specific components.
Breast-feeding
Consult a healthcare provider as safety in breastfeeding varies with specific components.
Storage
Store in a cool, dry place away from direct sunlight.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: haemodialysis
Haemodialysis is a medical procedure used to remove waste products and excess fluid from the blood when the kidneys are not functioning properly. It is primarily used in patients with end-stage renal disease or acute kidney injury. The process involves circulating the patient's blood through a dialyzer, which acts as an artificial kidney, allowing for the filtration of toxins and excess substances while retaining necessary components such as blood cells and proteins.
Indications
- End-stage renal disease
- Acute kidney injury
- Severe electrolyte imbalances (e.g., hyperkalemia)
- Toxin removal in cases of overdose or poisoning (e.g., salicylates, lithium)
- Fluid overload that is unresponsive to diuretics
Dosage
Children: In children, haemodialysis is also individualized based
Adults: The dosage and frequency of haemodialysis depend on individual patient needs, typically ranging from 3 to 5 sessions per week, with each session lasting about 3 to 5 hours.
Mechanism of action
Haemodialysis operates by the principles of diffusion and ultrafiltration. During the procedure, blood is drawn from the patient and passed through a dialyzer, where it encounters a semi-permeable membrane. Waste products and excess electrolytes diffuse from the blood into a dialysis solution (dialysate) that is flowing on the other side of the membrane, effectively cleaning the blood. The ultrafiltration process allows for the removal of excess fluid based on pressure gradients.
Pharmacodynamics
Haemodialysis effectively reduces levels of urea, creatinine, and other solutes in the blood, improves electrolyte balance, and alleviates symptoms of fluid overload such as hypertension and pulmonary congestion. It can also help correct metabolic acidosis and restore normal acid-base balance in patients with impaired renal function.
Pharmacokinetics
Haemodialysis does not have traditional pharmacokinetics as it is a dialysis procedure rather than a drug. However, the removal rates of various solutes depend on factors such as their molecular size, the dialyzer's surface area, blood and dialysate flow rates, and the duration of the treatment. The clearance of substances during haemodialysis can be quantified, allowing for adjustments in treatment protocols to optimize patient outcomes.
Adverse effects
- Hypotension
- Muscle cramps
- Nausea
- Headache
- Fatigue
- Infection at the access site
- Electrolyte imbalances
Precautions
- Monitor for signs of infection at the access site
- Assess blood pressure regularly during treatment
- Be cautious in patients with cardiovascular disease
- Evaluate electrolyte levels frequently
Pregnancy
Safety during pregnancy has not been established. Use only if clearly needed.
Breast-feeding
Safety during breastfeeding is not established. Consult a healthcare provider.
Storage
No specific storage requirements as it is performed in a clinical setting.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.