ACTOMIDE

Indications

• Functional dyspepsia
• Gastrointestinal motility disorders

Dosage

Children: Refer to the BNF for Children for specific dosing information.

Adults: Refer to the BNF for specific dosing information.

Mechanism of action

Acotiamide acts as a selective antagonist of the acetylcholine receptors, specifically the muscarinic M1 receptor subtype, which plays a pivotal role in modulating gastric smooth muscle contraction and gastric motility. By inhibiting this receptor, acotiamide enhances the release of acetylcholine in the gastrointestinal tract, promoting improved gastric motility and facilitating digestive processes.

Pharmacodynamics

The pharmacodynamic profile of acotiamide involves its ability to improve gastrointestinal motility and reduce symptoms associated with functional dyspepsia. The drug has a relatively rapid onset of action, leading to a reduction in symptoms such as nausea and bloating. It is also noted for its favorable side effect profile compared to other gastrointestinal agents.

Pharmacokinetics

Acotiamide is well absorbed after oral administration, with peak plasma concentrations typically occurring within 1 to 2 hours. The drug undergoes hepatic metabolism, primarily through cytochrome P450 enzymes, and is excreted in the urine. Its half-life is approximately 4 to 6 hours, which may necessitate multiple doses throughout the day to maintain therapeutic levels.

Pregnancy

There is limited data on the use of acotiamide in pregnancy. Caution is recommended.

Breast-feeding

It is not known if acotiamide is excreted in human milk. Caution is advised.

Storage

Store below 30 degrees Celsius. Keep in a dry place, protected from light.

Formulations

• {'form': 'tablet', 'strength': '100 mg'}