ALBUREL 20% 100ML

Indications

• Metabolic disorders
• Antimicrobial therapy
• Nutritional supplementation

Dosage

Children: Refer to the BNF for Children for appropriate dosing information, as paediatric doses differ based on age and weight.

Adults: Refer to the BNF for specific dosing guidelines, as dosing may vary depending on the condition being treated.

Mechanism of action

Caprylate exerts its effects through several mechanisms, primarily involving the modulation of fatty acid metabolism. It is known to be oxidized in the mitochondria to produce energy, contributing to cellular energy homeostasis. Additionally, caprylate has been shown to possess antimicrobial properties, which may be due to its ability to disrupt microbial cell membranes, leading to cell lysis.

Pharmacodynamics

Caprylate functions as an energy source and is involved in the regulation of lipid metabolism. It can influence the levels of various metabolites and has been linked to the modulation of inflammatory pathways. The antimicrobial action of caprylate contributes to its therapeutic potential in various infections.

Pharmacokinetics

Caprylate is rapidly absorbed and metabolized in the body. Following ingestion, it is transported via the lymphatic system to the bloodstream, where it is incorporated into lipoproteins. The medium-chain length of caprylate allows for quicker absorption compared to long-chain fatty acids. It is primarily metabolized in the liver, where it undergoes beta-oxidation to produce acetyl-CoA, which then enters the citric acid cycle for energy production.

Pregnancy

There is insufficient data on the use of caprylate during pregnancy. Consultation with a healthcare provider is recommended.

Breast-feeding

Limited data is available regarding the excretion of caprylate in human milk. Caution is advised when administering to breastfeeding women.

Storage

Store in a cool, dry place away from direct sunlight. Keep container tightly closed.