AMINOPHYLINE INJ.250MG/10ML 50'S
AMINOPHYLINE INJ.250MG/10ML 50'S
What it does
50's is a medication used for various health conditions.
Commonly used for: treating certain infections, managing pain or inflammation, supporting overall health
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 19:18:07 · updated 2026-08-03 02:03:30
About 50's
50's is a medication used for various health conditions.
What it treats
- treating certain infections
- managing pain or inflammation
- supporting overall health
How it works
It works by targeting specific pathways in the body to help improve health and relieve symptoms.
Who it's for
This medication is for adults and children who need treatment for specific health issues.
Cautions
- • Consult your doctor if you have allergies or are taking other medications.
- • Not recommended for people with certain health conditions.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About aminophyline
Aminophylline is a medication used to help relax the muscles in the airways, making it easier to breathe.
What it treats
- asthma
- chronic obstructive pulmonary disease (COPD)
- respiratory distress
How it works
It works by relaxing the muscles around the airways and helping to open them up, improving airflow to the lungs.
Who it's for
It is for people with breathing difficulties, such as those with asthma or COPD.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About inj
Inj is a medication used to treat various health conditions.
How it works
Inj works by affecting certain processes in the body to help manage symptoms or treat conditions.
Who it's for
Inj is prescribed for patients with specific medical needs as determined by a healthcare professional.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: aminophyline
Aminophylline is a bronchodilator that is a combination of theophylline and ethylenediamine. It is primarily used to treat respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), and bronchospasm associated with asthma. Aminophylline works by relaxing the smooth muscles of the airways, leading to improved airflow and decreased respiratory distress.
Indications
- Asthma
- Chronic obstructive pulmonary disease (COPD)
- Acute bronchospasm
- Respiratory distress syndrome in neonates
Dosage
Children: Refer to the BNF for Children for specific dosing recommendations tailored to the paediatric population.
Adults: Refer to specific dosing guidelines provided in clinical resources, as dosing may vary based on the condition being treated, patient response, and clinical factors.
Mechanism of action
Aminophylline is a non-selective phosphodiesterase inhibitor, which increases intracellular cAMP levels, leading to relaxation of bronchial smooth muscle. It also has anti-inflammatory effects and may enhance mucociliary clearance. Additionally, aminophylline antagonizes adenosine receptors, contributing to its bronchodilator effect.
Pharmacodynamics
Aminophylline exhibits a dose-dependent bronchodilator effect. The onset of action is typically within 30 minutes following intravenous administration, and the effects can last for several hours. Its therapeutic window is narrow, and monitoring of serum levels may be necessary to avoid toxicity. Common side effects include gastrointestinal disturbances, central nervous system stimulation, and cardiovascular effects such as tachycardia.
Pharmacokinetics
Aminophylline is rapidly absorbed after intravenous administration, with peak plasma concentrations occurring within minutes. It is metabolized in the liver through cytochrome P450 enzymes, primarily CYP1A2 and CYP3A4. The elimination half-life can vary significantly between individuals due to factors such as age, smoking status, and liver function. The drug is excreted primarily in urine, both as unchanged drug and metabolites.
Contra-indications
- Hypersensitivity to aminophylline or any of its components
- Peptic ulcer disease
- Seizure disorders
- Severe liver disease
- Cardiac arrhythmias
Adverse effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Tachycardia
- Palpitations
- Headache
- Insomnia
- Nervousness
- Dizziness
- Tremors
- Hypotension
- Arrhythmias
Interactions
- Increased risk of toxicity when used with other xanthines such as caffeine and theophylline
- May enhance the effects of beta-adrenergic agonists
- Interactions with certain antibiotics (e.g., erythromycin) can increase aminophylline levels
- Cimetidine can increase aminophylline concentrations
- Smoking may increase the clearance of aminophylline, leading to lower serum levels
Precautions
- Use with caution in patients with cardiovascular diseases
- Monitor patients with hepatic impairment closely
- Adjust dosing in elderly patients due to altered pharmacokinetics
- Careful monitoring required during concurrent use with drugs that can affect hepatic metabolism
Pregnancy
Aminophylline should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It crosses the placenta.
Breast-feeding
Aminophylline is excreted in breast milk, and caution should be exercised when administering to nursing mothers.
Storage
Store in a cool, dry place, protected from light. Keep out of reach of children.
Formulations
- Injectable solution
- Oral tablets
- Syrup
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.