Antisedan 10ml injection
Atipamezole hydrochloride
What it does
Atipamezole is used to reverse sedation caused by certain medications in animals.
Commonly used for: reversal of sedation in animals
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Sourcing - Kenya onlyRegistration & product details
Source: Zambia Medicines Regulatory Authority · fetched 2026-06-28 06:27:54 · updated 2026-10-19 03:40:28
About this medicine
Atipamezole is used to reverse sedation caused by certain medications in animals.
What it treats
- reversal of sedation in animals
How it works
Atipamezole works by blocking the effects of sedative drugs, helping the animal to wake up more quickly.
Who it's for
This medication is for use in animals that have been sedated.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: atipamezole
BNF-referencedAtipamezole is a selective alpha-2 adrenergic antagonist primarily used as a reversal agent for sedation induced by alpha-2 agonists in veterinary medicine. It acts by competitively inhibiting the alpha-2 adrenergic receptors, leading to a rapid reversal of sedation and analgesia caused by drugs such as medetomidine and dexmedetomidine. Its chemical structure is represented by the molecular formula C14H16N2.
Indications
- Reversal of sedation induced by alpha-2 agonists in veterinary medicine
- Management of sedation in animals
Dosage
Children: Refer to the BNF for Children for dosing information in paediatric patients.
Adults: Refer to the specific product label and veterinary guidelines for dosing information, as this can vary based on the specific alpha-2 agonist used and the condition being treated.
Mechanism of action
Atipamezole acts as an antagonist at central and peripheral alpha-2 adrenergic receptors. By blocking these receptors, it counteracts the effects of sedative agents, leading to increased release of norepinephrine and enhancement of sympathetic outflow, which results in arousal and normalization of cardiovascular parameters.
Pharmacodynamics
Atipamezole's pharmacodynamic effects include rapid reversal of sedation, restoration of normal physiological functions, and improvement of cardiovascular stability. It exhibits a high degree of selectivity for alpha-2 adrenergic receptors, which contributes to its efficacy in reversing sedation without causing significant stimulant effects.
Pharmacokinetics
Atipamezole is rapidly absorbed following parenteral administration. It has a relatively short half-life, allowing for quick recovery from sedation. The drug undergoes hepatic metabolism, and its metabolites are primarily excreted via the urine. The pharmacokinetic profile may vary based on the specific species and individual patient factors.
Adverse effects
- Sedation
- Tachycardia
- Hypotension
- Vomiting
- Diarrhea
Precautions
- Use with caution in animals with a history of cardiovascular disease.
- Monitor heart rate and blood pressure during administration.
Pregnancy
Safety in pregnancy has not been established.
Breast-feeding
Safety during lactation has not been established.
Storage
Store at room temperature, away from light and moisture.
Formulations
- Injectable solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: atipamezole
PubChem CID 71310Molecular formula: C14H16N2
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.