APLUTER INJECTION
α-β ARTEETHER
What it does
Arteether is a medication used to treat severe malaria, a serious infection caused by parasites.
Commonly used for: severe malaria, falciparum malaria
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:19:48 · updated 2026-07-26 09:19:06
About this medicine
Arteether is a medication used to treat severe malaria, a serious infection caused by parasites.
What it treats
- severe malaria
- falciparum malaria
How it works
Arteether works by killing the malaria parasites in the blood, helping to reduce the infection and symptoms.
Who it's for
Arteether is for people diagnosed with severe malaria, especially when other treatments may not be suitable.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: arteether
BNF-referencedArteether is an antimalarial medication derived from artemisinin, used primarily for the treatment of uncomplicated Plasmodium falciparum malaria. It is administered intramuscularly and is known for its rapid action against malaria parasites, particularly in cases where oral treatment is not feasible. Arteether is effective in reducing the parasite load, thus aiding in the recovery from malaria.
Indications
- Uncomplicated Plasmodium falciparum malaria
- Severe malaria when intravenous treatment is not possible
Dosage
Children: Refer to BNF for Children for specific dosing guidelines.
Adults: Refer to BNF for specific dosing guidelines.
Mechanism of action
Arteether exerts its antimalarial effects through the production of reactive oxygen species (ROS) that damage the parasites. The drug interacts with the heme moiety in the malaria parasite, leading to the generation of free radicals that are toxic to the parasite. This mechanism disrupts cellular function and ultimately results in the death of the malaria organism.
Pharmacodynamics
The pharmacodynamics of arteether involve rapid absorption and action against the malaria parasites. It is particularly effective against the asexual stages of the Plasmodium species. Arteether demonstrates a strong affinity for the parasites, leading to a quick reduction in parasitemia and alleviation of malaria symptoms. Its efficacy is enhanced when used in conjunction with other antimalarials.
Pharmacokinetics
Arteether is administered intramuscularly, leading to rapid systemic absorption. The drug is metabolized primarily in the liver, with its metabolites contributing to the antimalarial action. Arteether has a relatively short half-life, which necessitates careful dosing to maintain effective plasma concentrations. Renal and hepatic function can influence the pharmacokinetics of arteether, and dose adjustments may be required in patients with impaired function.
Pregnancy
There is limited data on the use of arteether in pregnant women. Its use should be considered only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
Arteether is excreted in breast milk. Caution should be exercised when arteether is administered to a nursing mother.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
Formulations
- Arteether injection
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: arteether
PubChem CID 3000469Molecular formula: C17H28O5
Mechanism of action
A 2025 systematic review notes that Arteether's pharmacological activity is antimalarial.
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.