ARISTOZYME LIQUID

Indications

• Carbohydrate malabsorption
• Digestive disorders
• Pancreatic insufficiency
• Postprandial distress

Dosage

Children: Refer to BNF for Children for specific dosing recommendations based on age and weight.

Adults: Refer to BNF for specific dosing recommendations based on clinical condition.

Mechanism of action

Diastase works by hydrolyzing glycosidic bonds in starch and glycogen, converting them into simpler sugars such as maltose and glucose. This enzymatic reaction occurs in the small intestine, enhancing the overall efficiency of carbohydrate digestion and absorption.

Pharmacodynamics

The pharmacodynamics of diastase is characterized by its ability to improve the digestion of carbohydrates. By increasing the availability of monosaccharides, it aids in nutrient absorption and can alleviate symptoms associated with malabsorption syndromes. The onset of action typically occurs shortly after administration, depending on the formulation and presence of food in the gastrointestinal tract.

Pharmacokinetics

Diastase is not absorbed systemically, as it acts locally within the gastrointestinal lumen. Its activity is influenced by the pH of the intestinal environment, with optimal activity occurring in a slightly alkaline medium. The enzyme is excreted with the feces, and its half-life is not generally measured, as it is not a drug that circulates in the bloodstream.

Pregnancy

The safety of diastase during pregnancy has not been established. Use only if clearly needed and after assessing risks versus benefits.

Breast-feeding

There are no data on the excretion of diastase in human milk, and caution is recommended when administering to nursing mothers.

Storage

Store at room temperature, protected from light and moisture. Keep out of reach of children.

Indications

• Dyspepsia
• Peptic ulcer disease
• Post-gastric surgery
• Protein malabsorption syndromes

Dosage

Children: Refer to the specific product guidelines for paediatric dosages, as they can vary based on formulation and indication.

Adults: Refer to the specific product guidelines for dosages, as they can vary based on formulation and indication.

Mechanism of action

Pepsin functions by cleaving peptide bonds in proteins, facilitating their breakdown into smaller polypeptides and amino acids. This process enhances protein digestion and absorption in the intestines. Pepsin preferentially hydrolyzes bonds adjacent to aromatic amino acids such as phenylalanine, tryptophan, and tyrosine.

Pharmacodynamics

Pepsin's activity is dependent on the pH of the environment, with maximal enzymatic activity occurring in acidic conditions. The enzyme's proteolytic action aids in the reduction of protein molecules into smaller fragments, which are then further digested by other enzymes in the small intestine. The presence of pepsin in the stomach helps to initiate the digestive process, promoting further digestive enzyme activity and nutrient absorption.

Pharmacokinetics

Pepsin is not absorbed systemically when ingested. It acts locally in the gastrointestinal tract, where it performs its enzymatic function. The half-life of pepsin in its active form is influenced by the pH and the presence of other digestive components. The enzyme is inactivated at a neutral to alkaline pH, thus limiting its action to the acidic environment of the stomach.

Pregnancy

Pepsin is generally considered safe during pregnancy, but it is advisable to consult a healthcare provider before use.

Breast-feeding

Pepsin is typically regarded as safe during breastfeeding, but consultation with a healthcare provider is recommended prior to use.

Storage

Store in a cool, dry place, away from direct sunlight and moisture.

Formulations

• Pepsin tablets
• Pepsin powder