AURONE
PHENAZONE
What it does
Phenazone is a medication used to relieve pain and reduce fever.
Commonly used for: pain relief, fever reduction
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Medicines Control Authority of Zimbabwe · fetched 2026-04-18 08:22:05 · updated 2026-10-21 04:30:03
About this medicine
Phenazone is a medication used to relieve pain and reduce fever.
What it treats
- pain relief
- fever reduction
How it works
Phenazone works by blocking certain chemicals in the body that cause pain and fever.
Who it's for
It is typically used for adults and children who need relief from pain or fever.
Cautions
- • Be cautious if you are taking medications that can harm the kidneys.
- • Avoid if you are on blood-thinning medications.
- • Use with care if you are taking drugs that can raise potassium levels in the blood.
- • Be careful if you are using medications that can lower sodium levels in the blood.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: phenazone
BNF-referencedPhenazone, also known as antipyrine, is a non-opioid analgesic and antipyretic agent used primarily for the relief of pain and fever. It works by modulating the body's pain response and reducing fever. Phenazone is often utilized in various formulations, including oral and topical applications, particularly in ear drops for ear pain relief.
Indications
- Pain relief
- Fever reduction
- Ear pain
- Testing drug metabolism
Dosage
Children: Refer to the BNF for Children for specific dosing guidance.
Adults: Refer to the BNF for specific dosing guidance.
Mechanism of action
Phenazone acts primarily in the central nervous system (CNS), increasing the pain threshold through the inhibition of cyclooxygenase enzymes, specifically COX-1, COX-2, and COX-3. This inhibition disrupts the synthesis of prostaglandins, which are mediators of pain and inflammation.
Pharmacodynamics
As an analgesic and antipyretic, phenazone serves to alleviate pain and reduce fever. It is frequently employed in pharmacological studies to assess the impact of other drugs or disease states on hepatic drug-metabolizing enzymes, demonstrating its importance in understanding drug interactions and metabolism.
Pharmacokinetics
Phenazone is absorbed well when administered orally. Its distribution in the body is extensive, and it is metabolized primarily in the liver, where it undergoes oxidation. The drug is excreted mainly through the kidneys. The elimination half-life can vary among individuals based on metabolic factors and liver function, necessitating caution in patients with hepatic impairment.
Adverse effects
- Nausea
- Vomiting
- Allergic reactions
- Skin rash
- Dizziness
Precautions
- Use with caution in patients with liver disease
- Monitor for signs of hypersensitivity
Pregnancy
Phenazone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is not known whether phenazone is excreted in human milk. Caution should be exercised when administering to a nursing mother.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
Formulations
- Oral tablets
- Ear drops
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: phenazone
PubChem CID 2206Molecular formula: C11H12N2O
Mechanism of action
Antipyrine is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis.
Pharmacodynamics
Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Biological pathways
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
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