Registered Malawi · PMRA

AUROZIL 500 500MG TABLET

CEFPROZIL

PMPB/PL132/59 TABLET antiinfectives for systemic use INN generic

What it does

Cefprozil is an antibiotic used to treat bacterial infections.

Commonly used for: bacterial infections, respiratory tract infections, skin infections, ear infections

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Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.

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Registration & product details

Registration no.
PMPB/PL132/59
Registration date
01/07/2007
Expiry date
30/06/2008
Status
Registered
Active ingredient
CEFPROZIL
Dosage form
TABLET
Strength
-
Pack size
-
Therapeutic class
-
ATC class (WHO)
J01DC - Second-generation cephalosporins
Drug group
ANTIINFECTIVES FOR SYSTEMIC USE
RxNorm RxCUI
19552
Manufacturer / MAH
-
Applicant / LTR
-
Country of origin
-

Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:38 · updated 2026-09-19 04:30:22

Disclaimer: This information is sourced from Pharmacy and Medicines Regulatory Authority (Malawi). Always consult a qualified healthcare professional before using any medication.

About this medicine

Cefprozil is an antibiotic used to treat bacterial infections.

What it treats

  • bacterial infections
  • respiratory tract infections
  • skin infections
  • ear infections

How it works

Cefprozil works by stopping the growth of bacteria, helping to eliminate the infection.

Who it's for

Cefprozil is suitable for adults and children who have bacterial infections.

AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.

Clinical monograph: cefprozil

BNF-referenced

Cefprozil is a semisynthetic, second-generation cephalosporin antibiotic that is effective against a variety of bacterial infections. It is primarily utilized in the treatment of otitis media, soft-tissue infections, and respiratory tract infections. Cefprozil is known for its stability against certain beta-lactamases, which enhances its efficacy compared to first-generation cephalosporins.

Indications

  • Otitis media
  • Soft-tissue infections
  • Respiratory tract infections

Dosage

Children: For children aged 6 months to 12 years, the recommended dose is 15 mg/kg (up to 500 mg) administered every 12 hours. For children under 6 months, consult the BNF for Children for appropriate dosing.

Adults: The usual oral dosage for adults is 500 mg every 12 hours or 1 g once daily, depending on the severity of the infection and the specific pathogen involved.

Mechanism of action

Cefprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefprozil interferes with an autolysin inhibitor.

Pharmacodynamics

Cefprozil exhibits bactericidal activity by disrupting the synthesis of the bacterial cell wall, leading to cell lysis and death. Its efficacy against a broad spectrum of gram-positive and some gram-negative bacteria makes it suitable for treating various infections. The drug is generally well-tolerated and is effective in both community-acquired infections and some resistant strains.

Pharmacokinetics

Cefprozil is well-absorbed following oral administration, with peak plasma concentrations occurring within 1 to 2 hours. It is approximately 35% bound to plasma proteins. Cefprozil is eliminated primarily via renal excretion, with a half-life of about 1 hour in individuals with normal renal function. Dosage adjustments may be necessary in patients with renal impairment.

Adverse effects

  • Diarrhea
  • Nausea
  • Vomiting
  • Rash
  • Allergic reactions
  • Elevated liver enzymes

Interactions

  • Probenecid may increase cefprozil levels
  • Anticoagulants may have increased effects

Precautions

  • Use with caution in patients with a history of penicillin allergy
  • Monitor renal function in patients with renal impairment
  • Caution in patients with gastrointestinal disease

Pregnancy

Cefprozil should only be used in pregnancy if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

Cefprozil is excreted in breast milk; caution should be exercised when administered to nursing mothers.

Storage

Store below 25°C, protect from light and moisture.

Formulations

  • Oral suspension
  • Tablets
PubChem / pathway

AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.

Molecular reference: cefprozil

PubChem CID 62977

Molecular formula: C18H19N3O5S

Mechanism of action

Cefprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefprozil interferes with an autolysin inhibitor.

Pharmacodynamics

Cefprozil, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections, and respiratory tract infections.

Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.

This drug in other countries

The same active ingredient registered across other registries we cover - including different brands.

Kenya 6 products