Avas-10

Atorvastatin - increases exposure

Diltiazem slightly increases the exposure to statins (atorvastatin). Monitor and adjust dose.

Atorvastatin - increases exposure

Cobicistat is predicted to increase the exposure to statins (atorvastatin). Avoid or adjust dose and monitor rhabdomyolysis.

Atorvastatin - increases exposure

Crizotinib is predicted to increase the exposure to statins (atorvastatin). Monitor and adjust dose.

Atorvastatin - increases exposure

Idelalisib is predicted to increase the exposure to statins (atorvastatin). Avoid or adjust dose and monitor rhabdomyolysis.

Atorvastatin - increases exposure

Imatinib is predicted to increase the exposure to statins (atorvastatin). Monitor and adjust dose.

Atorvastatin - increases exposure

Clarithromycin is predicted to increase the exposure to statins (atorvastatin). Avoid or adjust dose and monitor rhabdomyolysis.

Atorvastatin - increases exposure

Erythromycins slightly increases the exposure to statins (atorvastatin). Monitor and adjust dose.

Atorvastatin - decreases exposure

Tocilizumab is predicted to decrease the exposure to statins (atorvastatin, simvastatin). Monitor and adjust dose.

Atorvastatin - increases exposure

Nilotinib is predicted to increase the exposure to statins (atorvastatin). Monitor and adjust dose.

Atorvastatin - decreases exposure

Etravirine slightly decreases the exposure to statins (atorvastatin). Monitor and adjust dose.

Atorvastatin - increases exposure

Roxadustat is predicted to increase the exposure to statins (atorvastatin, pravastatin, rosuvastatin, simvastatin). Monitor adverse effects and adjust dose.

Atorvastatin - decreases exposure

Monoclonal antibodies (tocilizumab) are predicted to decrease the exposure to statins (atorvastatin, simvastatin). Monitor and adjust dose.

Statins - increases exposure

Amiodarone is predicted to increase the exposure to statins (atorvastatin). Monitor and adjust dose.

Statins - increases exposure

Dronedarone slightly increases the exposure to statins (atorvastatin). Monitor and adjust dose.

Statins - decreases exposure

Carbamazepine is predicted to decrease the exposure to statins (atorvastatin). Monitor and adjust dose. Also see TABLE 1 p. 1517.

Statins - decreases exposure

Eslicarbazepine is predicted to decrease the exposure to statins (atorvastatin). Monitor and adjust dose.

Statins - increases exposure

Fluconazole is predicted to increase the exposure to statins (atorvastatin, simvastatin). Monitor and adjust dose. Also see TABLE 1 p. 1517.

Statins - increases exposure

Diltiazem slightly increases the exposure to statins (atorvastatin). Monitor and adjust dose.

Statins - decreases exposure

Cenobamate is predicted to decrease the exposure to statins (simvastatin). Adjust dose.

Statins - increases exposure

Cobicistat is predicted to increase the exposure to statins (atorvastatin). Avoid or adjust dose and monitor rhabdomyolysis.

Statins - increases exposure

Crizotinib is predicted to increase the exposure to statins (atorvastatin). Monitor and adjust dose.

Statins - increases exposure

Eltrombopag is predicted to increase the exposure to statins. Monitor and adjust dose.

Statins - increases risk of rhabdomyolysis

Fenofibrate is predicted to increase the risk of rhabdomyolysis when given with statins (fluvastatin). Use with caution and adjust fenofibrate dose, p. 218.

Statins - increases exposure

Idelalisib is predicted to increase the exposure to statins (atorvastatin). Avoid or adjust dose and monitor rhabdomyolysis.

Statins - increases exposure

Imatinib is predicted to increase the exposure to statins (atorvastatin). Monitor and adjust dose.

Statins - increases exposure

Clarithromycin is predicted to increase the exposure to statins (atorvastatin). Avoid or adjust dose and monitor rhabdomyolysis.

Statins - increases exposure

Erythromycins slightly increases the exposure to statins (atorvastatin). Monitor and adjust dose.

Statins - decreases exposure

Tocilizumab is predicted to decrease the exposure to statins (atorvastatin, simvastatin). Monitor and adjust dose.

Statins - increases exposure

Nilotinib is predicted to increase the exposure to statins (atorvastatin). Monitor and adjust dose.

Statins - decreases exposure

Etravirine slightly decreases the exposure to statins (atorvastatin). Monitor and adjust dose.

Statins - increases exposure

Etravirine is predicted to increase the exposure to statins (fluvastatin). Adjust dose.

Statins - increases exposure

Roxadustat is predicted to increase the exposure to statins (atorvastatin, pravastatin, rosuvastatin, simvastatin). Monitor adverse effects and adjust dose.

Statins - decreases exposure

Monoclonal antibodies (tocilizumab) are predicted to decrease the exposure to statins (atorvastatin, simvastatin). Monitor and adjust dose.

Statins - increases exposure

Tucatinib is predicted to increase the exposure to statins (simvastatin). Avoid or adjust dose.

Atorvastatin - increases exposure

Isavuconazole slightly increases the exposure to statins (atorvastatin).

Atorvastatin - increases exposure

Cilostazolispredictedtoincreasetheexposuretostatins (atorvastatin).oTheoretical

Atorvastatin - decreases exposure

Dabrafenib is predicted to decrease the exposure to statins (atorvastatin, simvastatin).

Atorvastatin - increases exposure

Elbasvir with grazoprevir slightly increases the exposure to statins (atorvastatin). Adjust atorvastatin dose, p. 221.

Atorvastatin - increases exposure

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Atorvastatin - decreases exposure

Bosentan is predicted to decrease the exposure to statins (atorvastatin, simvastatin).

Atorvastatin - increases exposure

Fostemsavir is predicted to increase the exposure to statins (atorvastatin, fluvastatin, simvastatin). Adjust starting dose and monitor.

Atorvastatin - increases exposure

Grapefruit juice increases the exposure to statins (atorvastatin).

Atorvastatin - increases exposure

Grazoprevir moderately increases the exposure to statins (atorvastatin). Adjust atorvastatin dose, p. 221.

Atorvastatin - increases exposure

Leflunomide is predicted to increase the exposure to statins (atorvastatin, fluvastatin, pravastatin, simvastatin). Also see TABLE 1 p. 1517

Atorvastatin - increases exposure

Letermovir moderately increases the exposure to statins (atorvastatin). Avoid or adjust atorvastatin dose, p. 221.

Atorvastatin - increases exposure

Lomitapide increases the exposure to statins (atorvastatin). Adjust lomitapide dose or separate administration by 12 hours, p. 228. Also see TABLE 1 p. 1517.

Atorvastatin - decreases exposure

Mitotane is predicted to decrease the exposure to statins (atorvastatin, simvastatin).

Atorvastatin - decreases exposure

Sarilumab is predicted to decrease the exposure to statins (atorvastatin, simvastatin).

Atorvastatin - affects exposure

Pazopanib might affect the exposure to statins (atorvastatin, pravastatin, rosuvastatin).

Atorvastatin - increases exposure

Ranolazineispredictedtoincreasetheexposuretostatins (atorvastatin).oTheoretical

Atorvastatin - increases exposure

Regorafenib is predicted to increase the exposure to statins (atorvastatin, fluvastatin).

Atorvastatin - decreases exposure

Rifampicin markedly decreases the exposure to statins (atorvastatin). Manufacturer advises take both drugs at the same time.

Atorvastatin - decreases exposure

St John’s wort is predicted to decrease the exposure to statins (atorvastatin, simvastatin).

Atorvastatin - affects exposure

Taxanes (cabazitaxel) are predicted to affect the exposure to statins (atorvastatin, pravastatin, rosuvastatin, simvastatin). Manufacturer advises take 12 hours before or 3 hours after cabazitaxel.

Atorvastatin - increases exposure

Tepotinib might increase the exposure to statins (atorvastatin, fluvastatin, rosuvastatin).

Atorvastatin - increases exposure

Teriflunomide is predicted to increase the exposure to statins (atorvastatin, fluvastatin, pravastatin, simvastatin). Also see TABLE 1 p. 1517

Atorvastatin - increases exposure

Velpatasvir with sofosbuvir slightly increases the exposure to atorvastatin.

Atorvastatin - affects exposure

Cabazitaxel is predicted to affect the exposure to statins (atorvastatin, pravastatin, rosuvastatin, simvastatin). Manufacturer advises take 12 hours before or 3 hours after cabazitaxel.

Atorvastatin - increases exposure

Venetoclax is predicted to increase the exposure to statins (atorvastatin).

Daptomycin - increases risk of rhabdomyolysis

Statins are predicted to increase the risk of rhabdomyolysis when given with daptomycin. Daratumumab → see monoclonal antibodies Darbepoetin alfa → see TABLE 5 p. 1518 (thromboembolism), TABLE 16 p. 1

Daptomycin - increases risk of rhabdomyolysis e

Statins are predicted to increase the risk of rhabdomyolysis when given with daptomycin.

Statins - increases risk of rhabdomyolysis

Acipimox is predicted to increase the risk of rhabdomyolysis when given with statins. Theoretical Acitretin → see retinoids Aclidinium → see TABLE 10 p. 1519 (antimuscarinics)

Statins - decreases exposure

Apalutamide is predicted to decrease the exposure to statins (atorvastatin).

Statins - decreases exposure

Enzalutamide is predicted to decrease the exposure to statins (atorvastatin, simvastatin).

Statins - increases concentration

Darolutamide is predicted to increase the concentration of statins (pravastatin, simvastatin).

Statins - decreases exposure

Phenytoin moderately decreases the exposure to statins (atorvastatin).

Statins - decreases exposure

Oxcarbazepine is predicted to decrease the exposure to statins (atorvastatin, simvastatin).

Statins - increases exposure

Isavuconazole slightly increases the exposure to statins (atorvastatin).

Statins - increases exposure

Bempedoic acid increases the exposure to statins (pravastatin).

Statins - increases exposure

Bulevirtideispredictedtoincreasetheexposuretostatins. Avoidormonitor.oTheoretical

Statins - increases exposure

Amlodipine slightly increases the exposure to statins (simvastatin). Adjust simvastatin dose, p. 224.

Statins - increases concentration

Ceftobiproleispredictedtoincreasetheconcentrationof statins.oTheoretical

Statins - increases exposure

Ciclosporin moderately increases the exposure to statins (fluvastatin).

Statins - increases exposure

Cilostazolispredictedtoincreasetheexposuretostatins (atorvastatin).oTheoretical

Statins - increases exposure

Clopidogrel increases the exposure to statins (rosuvastatin). Adjust rosuvastatin dose, p. 223.

Statins - decreases exposure

Dabrafenib is predicted to decrease the exposure to statins (atorvastatin, simvastatin).

Statins - increases exposure

Dasatinib is predicted to increase the exposure to statins (simvastatin). Theoretical Daunorubicin → see anthracyclines Decitabine → see TABLE 15 p. 1520 (myelosuppression) Deferasirox → see iron chel

Statins - increases exposure

Elbasvir with grazoprevir slightly increases the exposure to statins (atorvastatin). Adjust atorvastatin dose, p. 221.

Statins - increases exposure

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Statins - decreases exposure

Bosentan is predicted to decrease the exposure to statins (atorvastatin, simvastatin).

Statins - increases exposure

Fostamatinibslightlyincreasestheexposuretostatins (rosuvastatin).oStudy 1xidneppA|snoitcaretnI A1 https://www.facebook.c (Books-Courses-Medic

Statins - increases exposure

Fostemsavir is predicted to increase the exposure to statins (atorvastatin, fluvastatin, simvastatin). Adjust starting dose and monitor.

Statins - increases exposure

Grapefruit juice increases the exposure to statins (atorvastatin).

Statins - increases exposure

Grazoprevir moderately increases the exposure to statins (atorvastatin). Adjust atorvastatin dose, p. 221.

Statins - affects exposure

HIV-protease inhibitors might affect the exposure to statins (pravastatin).

Statins - increases exposure

Leflunomide is predicted to increase the exposure to statins (atorvastatin, fluvastatin, pravastatin, simvastatin). Also see TABLE 1 p. 1517

Statins - increases exposure

Letermovir moderately increases the exposure to statins (atorvastatin). Avoid or adjust atorvastatin dose, p. 221.

Statins - increases exposure

Lomitapide increases the exposure to statins (atorvastatin). Adjust lomitapide dose or separate administration by 12 hours, p. 228. Also see TABLE 1 p. 1517.

Statins - increases exposure

Mifepristone moderately increases the exposure to statins (fluvastatin).

Statins - increases exposure

Mifepristone very markedly increases the exposure to statins (simvastatin).

Statins - decreases exposure

Mitotane is predicted to decrease the exposure to statins (atorvastatin, simvastatin).

Statins - decreases exposure

Sarilumab is predicted to decrease the exposure to statins (atorvastatin, simvastatin).

Statins - increases exposure

Olaparibispredictedtoincreasetheexposuretostatins. oTheoretical

Statins - affects exposure

Pazopanib might affect the exposure to statins (atorvastatin, pravastatin, rosuvastatin).

Statins - increases exposure

Ranolazineispredictedtoincreasetheexposuretostatins (atorvastatin).oTheoretical

Statins - increases exposure

Regorafenib is predicted to increase the exposure to statins (atorvastatin, fluvastatin).

Statins - increases exposure

Ribociclib is predicted to increase the exposure to statins (pravastatin, rosuvastatin). Theoretical

Statins - decreases exposure

Rifampicin markedly decreases the exposure to statins (atorvastatin). Manufacturer advises take both drugs at the same time.

Statins - decreases exposure

Rifampicin very markedly decreases the exposure to statins (simvastatin).

Statins - decreases exposure

St John’s wort is predicted to decrease the exposure to statins (atorvastatin, simvastatin).

Statins - affects exposure

Taxanes (cabazitaxel) are predicted to affect the exposure to statins (atorvastatin, pravastatin, rosuvastatin, simvastatin). Manufacturer advises take 12 hours before or 3 hours after cabazitaxel.

Statins - increases exposure

Tepotinib might increase the exposure to statins (atorvastatin, fluvastatin, rosuvastatin).

Statins - increases exposure

Teriflunomide is predicted to increase the exposure to statins (atorvastatin, fluvastatin, pravastatin, simvastatin). Also see TABLE 1 p. 1517

Statins - increases exposure

Venetoclax is predicted to increase the exposure to statins (fluvastatin, pravastatin, rosuvastatin, simvastatin).

Statins - affects exposure

Cabazitaxel is predicted to affect the exposure to statins (atorvastatin, pravastatin, rosuvastatin, simvastatin). Manufacturer advises take 12 hours before or 3 hours after cabazitaxel.

Statins - increases exposure

Ticagrelor slightly to moderately increases the exposure to statins (simvastatin). Adjust simvastatin dose, p. 224.

Statins - decreases exposure

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Statins - increases exposure

Velpatasvir with sofosbuvir slightly increases the exposure to statins (atorvastatin).