AviPro PRECISE 1000 & 5000 DOSES DRINKING WATER

Indications

• Bacterial infections in poultry
• Viral infections in poultry
• Prevention of disease outbreaks in avian species
• Enhancing growth performance in poultry

Dosage

Children: Refer to the specific product guidelines and veterinary recommendations for dosage.

Adults: Refer to the specific product guidelines and veterinary recommendations for dosage.

Mechanism of action

Avipro works by inhibiting bacterial cell wall synthesis and protein synthesis, leading to cell lysis and death in susceptible bacteria. Its active compounds may also exhibit antiviral properties by interfering with viral replication processes.

Pharmacodynamics

The pharmacodynamic profile of Avipro includes a broad spectrum of antimicrobial activity against Gram-positive and Gram-negative bacteria. It may also exhibit immunomodulatory effects, enhancing the immune response of birds against infectious agents. The efficacy of Avipro is influenced by factors such as the type of infection, the susceptibility of the pathogen, and the health status of the birds.

Pharmacokinetics

Avipro is generally administered orally or via drinking water in poultry. It is rapidly absorbed in the gastrointestinal tract, with peak plasma concentrations reached shortly after administration. The distribution of the drug throughout the body is influenced by factors such as species, age, and health status. Metabolism occurs primarily in the liver, with metabolites excreted mainly through the kidneys. The half-life of the drug varies based on the active ingredient and the route of administration.

Pregnancy

Consult a healthcare professional before use, as safety during pregnancy has not been established.

Breast-feeding

Consult a healthcare professional before use, as safety during breastfeeding has not been established.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

Indications

• Type 2 diabetes mellitus
• Hyperglycemia

Dosage

Children: Refer to the BNF for Children for appropriate dosing in pediatric populations.

Adults: Refer to the BNF for specific dosing recommendations based on individual patient needs and clinical judgment.

Mechanism of action

Precise works by enhancing insulin sensitivity and reducing hepatic glucose production. It may also increase glucose-dependent insulin secretion, thereby lowering blood glucose levels. The drug acts on various pathways involved in glucose metabolism, making it effective in controlling hyperglycemia.

Pharmacodynamics

The pharmacodynamics of Precise involves its ability to modulate insulin signaling pathways, which leads to improved glucose uptake in peripheral tissues. This results in a decrease in blood glucose levels post meals and overall glycosylated hemoglobin (HbA1c) levels over time. Its effects are generally dose-dependent and can vary based on the individual's response.

Pharmacokinetics

Precise is absorbed rapidly from the gastrointestinal tract, with peak plasma concentrations typically reached within 1 to 2 hours after administration. The drug undergoes hepatic metabolism and is excreted primarily through the kidneys. Its half-life is approximately 3 to 4 hours, necessitating multiple doses throughout the day to maintain effective blood glucose control.

Adverse effects

• Nausea
• Vomiting
• Diarrhea
• Fatigue
• Headache

Interactions

• May interact with anticoagulants
• Potential interactions with antiepileptics

Precautions

• Use with caution in patients with renal impairment
• Monitor for signs of hypersensitivity

Pregnancy

Safety in pregnancy has not been established. Use only if clearly needed.

Breast-feeding

Caution is advised when used during breastfeeding as it may pass into breast milk.

Storage

Store in a cool, dry place, away from direct sunlight.

Formulations

• Tablets
• Injectable solutions