BEDOIC TABLETS
BEMPEDOIC ACID
What it does
Bempedoic is a medication used to help lower cholesterol levels in the blood.
Commonly used for: high cholesterol (hyperlipidemia)
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 19:28:21 · updated 2026-09-29 02:20:39
About this medicine
Bempedoic is a medication used to help lower cholesterol levels in the blood.
What it treats
- high cholesterol (hyperlipidemia)
How it works
Bempedoic works by reducing the amount of cholesterol your body makes, which helps lower overall cholesterol levels.
Who it's for
This medication is for adults who have high cholesterol, especially those who may not be able to take statins.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: bempedoic
Bempedoic acid is a lipid-lowering agent that works by inhibiting ATP-citrate lyase, an enzyme involved in the synthesis of cholesterol and fatty acids. It is primarily used to reduce low-density lipoprotein cholesterol (LDL-C) levels in patients with hyperlipidemia, particularly those who are unable to achieve their LDL-C target with diet and maximally tolerated statin therapy.
Indications
- Hyperlipidemia
- Familial hypercholesterolemia
- Prevention of cardiovascular disease
Dosage
Children: Refer to BNF for Children for specific dosing guidelines, as bempedoic acid is not typically indicated for use in pediatric populations.
Adults: Refer to BNF for specific dosing guidelines, as dosage may vary based on individual patient factors.
Mechanism of action
Bempedoic acid inhibits ATP-citrate lyase, which reduces the production of acetyl-CoA in the liver. This leads to decreased cholesterol synthesis and subsequently lowers LDL-C levels. The reduction in cholesterol synthesis results in increased hepatic uptake of circulating LDL particles, promoting their clearance from the blood.
Pharmacodynamics
The pharmacodynamic effects of bempedoic acid include a significant reduction in LDL-C levels, which is achieved through its action on cholesterol biosynthesis pathways. The drug is often used in conjunction with statins or other lipid-lowering therapies to enhance cholesterol management in patients with dyslipidemia.
Pharmacokinetics
Bempedoic acid is well absorbed after oral administration, with peak plasma concentrations occurring within one hour. It undergoes extensive hepatic metabolism, primarily via UDP-glucuronosyltransferase enzymes. The elimination half-life is approximately 12 hours, and the drug is mainly excreted in the urine and feces.
Interactions
- bempedoic acid + statins: Unknown (increases exposure)
- bempedoic acid + pravastatin: Unknown (increases exposure)
- bempedoic acid + simvastatin: Unknown (increases exposure)
Pregnancy
Safety in pregnancy has not been established. Use only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is not known whether bempedoic acid is excreted in human milk. Caution should be exercised.
Storage
Store below 30 degrees Celsius, protect from moisture.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.