BETAMOX LA INJECTION
AMIXICILLIN TRIHYDRATE
What it does
Amoxicillin is an antibiotic that helps treat infections caused by bacteria.
Commonly used for: bacterial infections, pneumonia, ear infections (otitis media), throat infections (pharyngitis) …
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 22:06:33 · updated 2026-03-23 04:51:42
About this medicine
Amoxicillin is an antibiotic that helps treat infections caused by bacteria.
What it treats
- bacterial infections
- pneumonia
- ear infections (otitis media)
- throat infections (pharyngitis)
- sinus infections (sinusitis)
- urinary tract infections
How it works
It works by stopping the growth of bacteria, helping your body to fight off the infection.
Who it's for
It is for people who have bacterial infections that are sensitive to amoxicillin.
Cautions
- • Inform your doctor if you have allergies to penicillin or other antibiotics.
- • Tell your doctor if you have liver or kidney problems.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: amixicillin
Amoxicillin is a broad-spectrum penicillin antibiotic used to treat various bacterial infections. It is effective against a wide range of Gram-positive and some Gram-negative bacteria, making it a commonly prescribed antibiotic for conditions such as pneumonia, bronchitis, and infections of the ear, nose, and throat.
Indications
- Otitis media
- Sinusitis
- Pneumonia
- Bronchitis
- Urinary tract infections
- Skin and soft tissue infections
- Gastric ulcers caused by Helicobacter pylori
Dosage
Children: Refer to the BNF for Children for specific dosing information.
Adults: Refer to the BNF for specific dosing information.
Mechanism of action
Amoxicillin works by inhibiting the synthesis of bacterial cell walls. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, leading to the disruption of cell wall synthesis and ultimately causing cell lysis and death. This action is particularly effective against actively multiplying bacteria.
Pharmacodynamics
The pharmacodynamics of amoxicillin is characterized by its time-dependent bactericidal activity. The antibiotic exerts its effects primarily during the time that the drug concentration exceeds the minimum inhibitory concentration (MIC) for the target bacteria. The efficacy of amoxicillin is also influenced by the susceptibility of the bacteria, the site of infection, and the immune response of the host.
Pharmacokinetics
Amoxicillin is well-absorbed from the gastrointestinal tract, with peak plasma concentrations typically occurring within 1 to 2 hours after oral administration. It exhibits a volume of distribution of approximately 0.3 to 0.4 L/kg. The drug is metabolized in the liver to a minor extent, but primarily excreted unchanged by the kidneys, making renal function a critical factor in its clearance. The half-life of amoxicillin is around 1 to 1.5 hours in healthy adults.
Contra-indications
- Hypersensitivity to amoxicillin, penicillins, or any component of the formulation
- History of severe allergic reactions (e.g., anaphylaxis) to beta-lactam antibiotics
Adverse effects
- Nausea
- Vomiting
- Diarrhea
- Rash
- Urticaria
- Anaphylaxis
- Hepatic dysfunction
- Renal impairment
Interactions
- Probenecid may increase amoxicillin levels by decreasing renal excretion
- Anticoagulants may have increased effects when used with amoxicillin
- Methotrexate clearance may be reduced by amoxicillin
Precautions
- Use with caution in patients with a history of gastrointestinal disease, particularly colitis
- Monitor renal function in patients with renal impairment
- Assess for signs of a superinfection during prolonged therapy
Pregnancy
Amoxicillin is generally considered safe for use during pregnancy, particularly in cases where the benefits outweigh the risks. Consult a healthcare provider for individual assessment.
Breast-feeding
Amoxicillin is excreted in breast milk in small amounts. It is generally considered safe for use while breastfeeding, but monitoring for potential effects in the infant is advisable.
Storage
Store in a cool, dry place away from direct sunlight. After reconstitution, store in a refrigerator and use within the specified time frame.
Formulations
- Tablets
- Capsules
- Oral suspension
- Injection
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.