What it does
Menotrophin is a medication used to help treat fertility issues by stimulating the ovaries to produce eggs.
Commonly used for: infertility, ovarian stimulation
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Source: Tanzania Medicines and Medical Devices Authority · fetched 2026-03-11 23:43:56 · updated 2026-09-17 03:00:44
About this medicine
Menotrophin is a medication used to help treat fertility issues by stimulating the ovaries to produce eggs.
What it treats
- infertility
- ovarian stimulation
How it works
Menotrophin contains hormones that encourage the ovaries to produce eggs, which is important for women trying to conceive.
Who it's for
This medication is for women who have difficulty getting pregnant due to issues with egg production.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: Menotrophin
BNF-referencedMenotrophin is a gonadotropin preparation containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH). It is used in fertility treatments to stimulate the ovaries in women with certain types of infertility, particularly those with hypopituitarism or who have not responded to clomifene.
Indications
- Gonadotropin replacement therapy
- Treatment of infertility in women with proven hypopituitarism
- Superovulation for assisted conception, such as in vitro fertilization
Dosage
Adults: Initial dosing should be based on serum anti-Müllerian hormone concentration and body weight. Adjust doses according to response, under specialist supervision.
Mechanism of action
Menotrophin works by mimicking the natural hormones FSH and LH, which stimulate the ovaries to produce mature follicles. FSH promotes the growth and maturation of ovarian follicles, while LH triggers ovulation. This coordinated action is essential for the development of eggs and the regulation of the menstrual cycle.
Pharmacodynamics
Menotrophin enhances ovarian response in women undergoing assisted reproductive techniques by facilitating follicular development and maturation. It is crucial in protocols for in vitro fertilization (IVF) as it increases the number of viable oocytes available for retrieval.
Pharmacokinetics
After subcutaneous administration, menotrophin is absorbed into the bloodstream, with peak serum concentrations occurring after a variable time depending on the individual. The elimination half-life is not well-defined, but the hormone activity is generally maintained to support ovarian stimulation over several days. The pharmacokinetics can be influenced by the individual's hormonal status and response to treatment.
Contra-indications
- Mammary carcinoma
- Uterine carcinoma
- Ovarian hyperstimulation syndrome
- Pelvic disorders
Adverse effects
- Fatigue
- Headache
- Nausea
- Gastrointestinal discomfort
- Pelvic pain
- Vomiting
- Thromboembolism
- Ovarian and fallopian tube disorders
Precautions
- Regular monitoring of ovarian response with ultrasound or in combination with serum estradiol levels is required.
- Patients should be advised to withhold hCG and avoid intercourse or use barrier contraceptive methods for at least 4 days if ovarian hyperstimulation syndrome occurs.
Pregnancy
Manufacturer advises to avoid-not indicated during pregnancy.
Breast-feeding
Manufacturer advises to avoid-not indicated during breastfeeding.
Storage
Store in a refrigerator (2°C to 8°C). Do not freeze.
Formulations
- Powder and solvent for solution for injection vials
- Pre-filled disposable injection pens
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.