What it does
Bupavarquone is a medication used to treat certain infections caused by parasites.
Commonly used for: infections caused by parasites
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:57:30 · updated 2026-07-26 13:39:42
About this medicine
Bupavarquone is a medication used to treat certain infections caused by parasites.
What it treats
- infections caused by parasites
How it works
Bupavarquone works by targeting and killing the parasites that cause the infection.
Who it's for
It is used for individuals diagnosed with specific parasitic infections.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: bupavarquone
Bupavarquone is an investigational drug that is being studied for its potential use as an antiprotozoal agent, particularly for the treatment of certain parasitic infections. It belongs to a class of compounds known for their ability to inhibit mitochondrial function in parasites, leading to cell death. Its specific application is primarily in the context of treating infections caused by pathogens such as Trypanosoma and Leishmania species.
Indications
- Trypanosomiasis
- Leishmaniasis
- Other protozoal infections
Dosage
Children: Refer to clinical guidelines or specific product information for pediatric dosing recommendations.
Adults: Refer to clinical guidelines or specific product information for dosing recommendations.
Mechanism of action
Bupavarquone exerts its effects by inhibiting the mitochondrial respiratory chain in parasites, specifically targeting the cytochrome bc1 complex. This inhibition disrupts the electron transport chain, leading to a decrease in ATP production, which is critical for the survival and replication of the parasitic organisms. This mechanism is similar to that of other antiprotozoal agents that affect mitochondrial function.
Pharmacodynamics
Bupavarquone demonstrates a concentration-dependent killing effect on protozoan parasites. The drug's efficacy is influenced by its ability to accumulate within the mitochondrial environment of the parasites, where it can effectively disrupt energy metabolism. The selectivity for parasitic cells over mammalian cells contributes to its therapeutic potential, though its safety profile is still under investigation.
Pharmacokinetics
The pharmacokinetic properties of bupavarquone are still being characterized in clinical studies. Initial data suggest that it may exhibit moderate oral bioavailability, with variable absorption depending on formulation and food intake. The drug is likely to undergo hepatic metabolism, with metabolites excreted primarily via the urine. The elimination half-life and clearance rates remain to be fully elucidated through ongoing research.
Adverse effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Anorexia
- Fatigue
- Headache
- Dizziness
- Rash
- Elevated liver enzymes
Precautions
- Use with caution in patients with liver impairment
- Monitor for potential hepatotoxicity
- Assess for drug interactions with other hepatically metabolized agents
Pregnancy
Bupavarquone should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is not known if bupavarquone is excreted in human milk. Caution should be exercised when administering to a nursing mother.
Storage
Store in a cool, dry place away from light. Keep out of reach of children.
Formulations
- Oral tablets
- Injectable solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.