What it does
Arthemether is a medicine used to treat malaria, a serious disease caused by parasites transmitted through mosquito bites.
Commonly used for: malaria
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:11:04 · updated 2026-08-03 04:11:16
About this medicine
Arthemether is a medicine used to treat malaria, a serious disease caused by parasites transmitted through mosquito bites.
What it treats
- malaria
How it works
Arthemether works by killing the malaria parasites in the blood, helping to reduce the symptoms and clear the infection.
Who it's for
This medicine is for adults and children diagnosed with malaria.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: arthemether
Arthemeter is an antimalarial medication derived from artemisinin, used primarily in the treatment of uncomplicated Plasmodium falciparum malaria. It is known for its rapid action against malaria parasites and is often utilized in combination therapies to enhance efficacy and reduce the risk of resistance. Arthemeter is particularly valuable in regions where malaria is endemic, providing effective treatment options for both adults and children.
Indications
- Uncomplicated Plasmodium falciparum malaria
- Treatment of malaria in combination with other antimalarial agents
Dosage
Children: Refer to BNF for Children for specific dosing recommendations.
Adults: Refer to clinical guidelines or BNF for specific dosing recommendations.
Mechanism of action
Arthemeter exerts its antimalarial effects through the generation of free radicals when activated by iron in the parasite. These free radicals damage the parasite's cellular components, including proteins and lipids, leading to the death of the malaria organisms. The drug is particularly effective against the asexual forms of the Plasmodium species.
Pharmacodynamics
Arthemeter has a rapid onset of action, with its effects typically observed within a few hours of administration. The drug targets the intraerythrocytic stages of Plasmodium falciparum, disrupting the parasite's metabolism and growth. Its effectiveness is enhanced when used in combination with other antimalarial agents, reducing the likelihood of developing resistance and improving overall treatment outcomes.
Pharmacokinetics
Arthemeter is well absorbed after oral administration, with peak plasma concentrations occurring within 2 to 3 hours. It has a short half-life, necessitating multiple doses for sustained efficacy. The drug is extensively metabolized in the liver, primarily through oxidative pathways, with metabolites that also possess antimalarial activity. Excretion occurs mainly through the urine, with some elimination via feces.
Adverse effects
- Nausea
- Vomiting
- Headache
- Dizziness
- Fatigue
- Diarrhea
- Abdominal pain
- Anemia
- Hypersensitivity reactions
Interactions
- May interact with other antimalarial agents
- Potential interactions with drugs that affect liver enzymes
Precautions
- Use with caution in patients with liver impairment
- Monitor for signs of hypersensitivity
- Caution in patients with a history of seizures
Pregnancy
Amehtmer is classified as category C. The benefits may outweigh the risks in treating severe malaria.
Breast-feeding
It is not known whether artemether is excreted in human milk. Caution is advised when administering to nursing mothers.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Formulations
- Oral tablets
- Injectable formulations
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.