CEFRACEF 250 CAPSULE
CEFRADINE MONOHYDRATE BP EQ.TO CEFRADINE
What it does
Cefradine is an antibiotic that helps fight bacterial infections in the body.
Commonly used for: bacterial infections, respiratory tract infections, urinary tract infections, skin infections
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:42:04 · updated 2026-07-26 11:32:38
Drug Interactions
3Pharmacodynamic Warnings
Cefradine appears in TABLE 2: Drugs that cause nephrotoxicity
Unknown (3)
Cephalosporins - increases exposure
Leflunomideispredictedtoincreasetheexposureto cephalosporins(cefaclor).oTheoretical
Cephalosporins - increases exposure
Nitisinone is predicted to increase the exposure to cephalosporins (cefaclor).
Cephalosporins - increases exposure
Teriflunomide is predicted to increase the exposure to cephalosporins (cefaclor).
Data from BNF 85 (British National Formulary). This is not a substitute for professional medical advice. Matched via: class
About this medicine
Cefradine is an antibiotic that helps fight bacterial infections in the body.
What it treats
- bacterial infections
- respiratory tract infections
- urinary tract infections
- skin infections
How it works
Cefradine works by killing bacteria or preventing their growth, helping the body to recover from infections.
Who it's for
Cefradine is suitable for people with bacterial infections, as directed by a healthcare provider.
Drug class
Cephalosporins
Cautions
- • Be cautious if you are taking other medications that may harm the kidneys.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: Cefradine
BNF-referencedCefradine is a first generation cephalosporin antibiotic with a spectrum of activity primarily against Gram-positive bacteria, and some Gram-negative bacteria. It is commonly used to treat various bacterial infections, including respiratory tract infections, skin infections, and urinary tract infections. Cefradine works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death of the bacteria.
Indications
- Susceptible infections due to sensitive Gram-positive and Gram-negative bacteria
- Respiratory tract infections
- Skin infections
- Urinary tract infections
- Surgical prophylaxis
Dosage
Children: In children aged 1–11 months, the usual dose is 40 mg/kg daily in 3 divided doses, with a maximum of 1 g daily. For children aged 1
Adults: Adults typically receive 250 mg to 500 mg three times a day, with a maximum dose of 4 g per day, depending on the severity of the infection.
Mechanism of action
Cefradine, as a beta-lactam antibiotic, binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding inhibits the third and final stage of bacterial cell wall synthesis. Subsequently, bacterial cell lysis is mediated by autolytic enzymes such as autolysins. Cefradine disrupts the cell wall integrity, leading to bacterial death, particularly effective against Gram-positive organisms.
Pharmacodynamics
Cefradine exhibits time-dependent antibacterial activity, with a prolonged effect due to its mechanism of cell wall synthesis inhibition. Its efficacy is influenced by the concentration of the drug at the site of infection, and it shows a favorable pharmacodynamic profile against susceptible bacteria. Resistance mechanisms may include the production of beta-lactamases, alteration of PBPs, or reduced permeability of the bacterial cell wall.
Pharmacokinetics
Cefradine is well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring approximately 1-2 hours after oral administration. It is distributed widely throughout body tissues and fluids, crossing the placental barrier and appearing in breast milk in low concentrations. The drug is primarily excreted unchanged in the urine, necessitating dose adjustments in patients with renal impairment. The half-life of cefradine is approximately 1-2 hours.
Adverse effects
- Agitation
- Confusion
- Fatigue
Precautions
- Dose adjustments may be necessary in renal impairment.
Pregnancy
Not known to be harmful.
Breast-feeding
Present in milk in low concentration, but appropriate to use.
Storage
Store in a cool, dry place away from light.
Formulations
- Powder for solution for injection
- Oral tablets
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: Cefradine
PubChem CID 38103Molecular formula: C16H19N3O4S
Mechanism of action
Cefradine is a first generation cephalosporin antibiotic with a spectrum of activity similar to Cefalexin. Cefradine, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Cefradine interferes with an autolysin inhibitor. Cephalosporins and cephamycins inhibit bacterial cell wall synthesis in a manner similar to that of penicillin. /Cephalosporins/ The first generation cephalosporins ... have activity against gram positive bacteria and relatively modest activity against gram negative microorganisms. /Cephalosporins/
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.