CEFTRAXONE INJ 1GM + H2O FOR INJ. 10ML 1'S
CEFTRAXONE INJ 1GM + H2O FOR INJ. 10ML 1'S
What it does
Ceftriaxone is an antibiotic used to treat infections caused by bacteria.
Commonly used for: bacterial infections, pneumonia, meningitis, skin infections …
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 19:21:20 · updated 2026-08-03 02:07:33
About ceftraxone
Ceftriaxone is an antibiotic used to treat infections caused by bacteria.
What it treats
- bacterial infections
- pneumonia
- meningitis
- skin infections
- urinary tract infections
How it works
Ceftriaxone works by killing bacteria or stopping their growth, helping the body fight off the infection.
Who it's for
Ceftriaxone is for individuals with bacterial infections as advised by a healthcare professional.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About inj
Inj is a medication used to treat various health conditions.
How it works
Inj works by affecting certain processes in the body to help manage symptoms or treat conditions.
Who it's for
Inj is prescribed for patients with specific medical needs as determined by a healthcare professional.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: ceftraxone
Ceftriaxone is a broad-spectrum cephalosporin antibiotic that is effective against a variety of gram-positive and gram-negative bacteria. It is commonly used to treat infections such as pneumonia, meningitis, and infections of the skin, soft tissues, and urinary tract. The drug is known for its long half-life, allowing for once-daily dosing in many cases.
Indications
- Bacterial meningitis
- Pneumonia
- Urinary tract infections
- Skin and soft tissue infections
- Intra-abdominal infections
- Septicemia
- Bone and joint infections
Dosage
Children: Refer to the BNF for Children for appropriate dosing based on the child's age and weight.
Adults: Refer to the BNF for specific dosing information based on the infection being treated.
Mechanism of action
Ceftriaxone works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, disrupting the cross-linking of peptidoglycan chains, which are essential for maintaining cell wall integrity. This leads to cell lysis and death of the bacteria.
Pharmacodynamics
Ceftriaxone exhibits time-dependent bactericidal activity, meaning its effectiveness is related to the time the drug concentration remains above the minimum inhibitory concentration (MIC) for the target bacteria. It has a broad spectrum of activity, particularly effective against Enterobacteriaceae, Streptococcus pneumoniae, and Neisseria gonorrhoeae.
Pharmacokinetics
Ceftriaxone is well absorbed when administered intravenously or intramuscularly. It is widely distributed in body tissues and fluids, including the central nervous system, achieving therapeutic concentrations in the cerebrospinal fluid. The drug is primarily excreted unchanged in the urine and bile, with a half-life of approximately 6-8 hours in adults, allowing for once-daily dosing. Adjustments may be necessary in cases of renal impairment.
Contra-indications
- Hypersensitivity to ceftriaxone or any of the excipients.
- History of severe allergic reactions to penicillins or other cephalosporins.
- Neonates with jaundice or hyperbilirubinemia.
Adverse effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Allergic reactions including anaphylaxis
- Hematologic reactions such as thrombocytopenia and leukopenia
- Elevated liver enzymes
- Renal impairment
- C. difficile-associated diarrhea
Interactions
- Calcium-containing products (risk of precipitation)
- Anticoagulants (may enhance anticoagulant effect)
- Aminoglycosides (increased nephrotoxicity)
- Probenecid (decreases renal excretion of ceftriaxone)
Precautions
- Caution in patients with a history of gastrointestinal disease, particularly colitis.
- Use with caution in patients with renal impairment.
- Monitor for signs of superinfection, particularly in patients receiving prolonged therapy.
Pregnancy
Ceftriaxone is classified as Category B. It should be used during pregnancy only if clearly needed.
Breast-feeding
Ceftriaxone is excreted in breast milk, caution is advised when administered to nursing mothers.
Storage
Store in a cool, dry place at room temperature. Protect from light. Reconstituted solutions should be used immediately or stored in a refrigerator and used within 24 hours.
Formulations
- Injectable solution for intravenous or intramuscular use.
- Powder for reconstitution.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.