CEFUZIME 500MG TABLETS

Indications

• Bacterial pneumonia
• Urinary tract infections
• Skin and soft tissue infections
• Intra-abdominal infections
• Otitis media
• Sinusitis

Dosage

Children: Refer to the BNF for Children for appropriate dosing information based on age and weight.

Adults: Refer to current clinical guidelines and local protocols for specific dosing recommendations.

Mechanism of action

Cefuzime exerts its antibacterial effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, disrupting the cross-linking of peptidoglycan chains that provide structural integrity to the cell wall. This leads to cell lysis and death, particularly in actively dividing bacteria.

Pharmacodynamics

The pharmacodynamics of cefuzime are characterized by its time-dependent killing activity, where the efficacy is related to the duration of time the drug concentration remains above the minimum inhibitory concentration (MIC) of the target pathogens. Cefuzime has a broad spectrum of activity against a variety of bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, and various Enterobacteriaceae. Its effectiveness may be influenced by the presence of beta-lactamase enzymes produced by resistant bacteria.

Pharmacokinetics

Cefuzime demonstrates favorable pharmacokinetic properties, with good distribution throughout body tissues and fluids. Following parenteral administration, it achieves peak plasma concentrations relatively quickly. The drug is primarily eliminated through renal excretion, with a half-life that generally allows for once or twice daily dosing. Adjustment of dosage may be necessary in patients with impaired renal function to avoid accumulation and potential toxicity.

Contra-indications

• Hypersensitivity to cefuzime or other cephalosporins
• Severe allergic reactions to penicillins

Adverse effects

• Nausea
• Diarrhea
• Rash
• Allergic reactions
• Elevated liver enzymes
• Nephrotoxicity
• Thrombocytopenia

Interactions

• Probenecid may increase cefuzime levels by reducing renal clearance
• Anticoagulants may have an enhanced effect when used with cefuzime
• Other nephrotoxic drugs may increase the risk of kidney damage

Precautions

• Use with caution in patients with renal impairment
• Monitor for signs of anaphylaxis in patients with a history of allergies
• Caution in patients with gastrointestinal disease, especially colitis

Pregnancy

Cefuzime is generally considered safe during pregnancy but should be used only if clearly needed.

Breast-feeding

Cefuzime is excreted in breast milk, caution is advised when administering to nursing mothers.

Storage

Store at controlled room temperature, away from moisture and light.

Formulations

• Oral tablets
• Injectable solution