CHYMORAL FORTE 100 000 ARMOUR UNITS TABLET
TRYPSIN-CHYMOTRYPSIN
What it does
Trypsin-chymotrypsin are digestive enzymes that help break down proteins in the body.
Commonly used for: digestive issues (malabsorption), pancreatitis, certain gastrointestinal disorders
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:42 · updated 2026-09-22 04:33:03
About this medicine
Trypsin-chymotrypsin are digestive enzymes that help break down proteins in the body.
What it treats
- digestive issues (malabsorption)
- pancreatitis
- certain gastrointestinal disorders
How it works
These enzymes help the body digest and absorb nutrients from food by breaking down proteins into smaller pieces.
Who it's for
This medication is for people who have trouble digesting food due to a lack of digestive enzymes.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: trypsinchymotrypsin
Trypsin and chymotrypsin are proteolytic enzymes that play a critical role in the digestion of proteins in the small intestine. They are derived from the pancreas and are secreted in their inactive forms (trypsinogen and chymotrypsinogen) before being activated in the intestinal lumen. These enzymes hydrolyze peptide bonds in proteins, facilitating their breakdown into smaller peptides and amino acids, which can then be absorbed by the body. Trypsin specifically cleaves on the carboxyl side of lysine and arginine residues, while chymotrypsin preferentially targets aromatic amino acids such as phenylalanine, tryptophan, and tyrosine.
Indications
- Pancreatic insufficiency
- Digestive disorders
- Protein malabsorption syndromes
- Post-surgical digestive support
Dosage
Adults: Refer to specific guidelines for dosing, as it can vary based on clinical condition
Mechanism of action
Trypsin and chymotrypsin exert their effects by cleaving peptide bonds in proteins. The activation of trypsinogen to trypsin occurs through the action of enteropeptidase, which is released from the intestinal mucosa. Activated trypsin then activates chymotrypsinogen to chymotrypsin, creating a cascade of proteolytic activity. This enzymatic action results in the breakdown of dietary proteins into smaller peptides and amino acids for absorption, facilitating nutrient utilization.
Pharmacodynamics
The pharmacodynamics of trypsin and chymotrypsin involve the modulation of protein digestion and absorption. By hydrolyzing peptide bonds, these enzymes enhance the digestion of dietary proteins, leading to improved nutrient availability. The efficiency of protein digestion is crucial for overall metabolic health, particularly in cases of pancreatic insufficiency or conditions where protein absorption may be impaired.
Pharmacokinetics
The pharmacokinetics of trypsin and chymotrypsin are characterized by their local action in the gastrointestinal tract. Once secreted into the small intestine, they act immediately on dietary proteins. They do not have systemic absorption in healthy individuals, as they are intended to function within the gastrointestinal lumen. The half-life of these enzymes is relatively short due to their rapid action and subsequent degradation by other proteolytic enzymes present in the intestinal environment.
Pregnancy
There are no well-controlled studies in pregnant women. Use only if clearly needed and the potential benefits justify the potential risks to the fetus.
Breast-feeding
It is not known whether trypsin-chymotrypsin is excreted in human milk. Caution should be exercised when administering to nursing mothers.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.