Cobactan 2.5%

Indications

• Bacterial infections in veterinary medicine
• Treatment of respiratory tract infections
• Treatment of skin and soft tissue infections
• Treatment of urinary tract infections

Dosage

Children: Paediatric dosing should be guided by the BNF for Children. It is essential to refer to the specific dosing guidelines for children based on age, weight, and condition being treated.

Adults: The dosage for adults should be determined based on the specific condition being treated and the guidelines provided in the BNF. Consult the BNF for appropriate dosing recommendations.

Mechanism of action

Cefquinome works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), which are essential for the cross-linking of peptidoglycan layers in bacterial cell walls. This leads to the disruption of cell wall integrity and ultimately results in bacterial lysis and death.

Pharmacodynamics

The pharmacodynamics of cefquinome involve its bactericidal activity, which is primarily time-dependent. The drug exhibits a prolonged post-antibiotic effect against certain bacteria, meaning it continues to inhibit bacterial growth even after serum levels have dropped below the MIC (minimum inhibitory concentration). Cefquinome is effective against a range of bacteria, including those that are resistant to other antibiotics.

Pharmacokinetics

Cefquinome is administered parenterally, with good bioavailability observed following intramuscular injection. It is widely distributed throughout the body, achieving therapeutic levels in various tissues. The drug is metabolized in the liver and is excreted primarily in the urine. The elimination half-life is approximately 1 to 2 hours, necessitating multiple doses for sustained therapeutic effect.

Pregnancy

Cefquinome should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

Cefquinome is excreted in breast milk. Caution should be exercised when administering to nursing mothers.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

Formulations

• {'formulation': 'Cefquinome injection', 'strength': '100 mg/ml'}