CODACTIV FORT

Indications

• Dry cough
• Cough associated with upper respiratory tract infections
• Cough due to bronchitis
• Cough as a symptom of allergic rhinitis

Dosage

Children: For children aged 6 to 12 years, the recommended dosage is 5 to 10 mg three times a day. For children under 6 years, dosing should be determined by a healthcare professional, and it is advisable to consult the BNF for Children for specific guidance.

Adults: The usual adult dosage of butamirate is 15 mg three times a day. It is important to follow the prescribing information or consult a healthcare professional for specific dosing instructions.

Mechanism of action

Butamirate acts centrally on the cough center in the medulla oblongata, reducing the cough reflex. It is believed to inhibit the activity of the afferent pathways of the cough reflex, thus decreasing the urge to cough. Additionally, it may have a mild bronchodilator effect, which can help ease respiratory symptoms.

Pharmacodynamics

The pharmacodynamics of butamirate involve its action on the central nervous system, specifically in modulating the cough reflex. Its effectiveness in reducing cough is attributed to its ability to suppress the neural pathways responsible for the cough response, without causing drowsiness or respiratory depression, which is often seen with traditional narcotic cough suppressants.

Pharmacokinetics

Butamirate is absorbed from the gastrointestinal tract and undergoes extensive metabolism in the liver. Its half-life and the exact pathways of metabolism are not well-documented, but it is known to be excreted mainly in urine. The onset of action typically occurs within a few hours of administration, providing relatively quick relief from cough symptoms.

Contra-indications

• Hypersensitivity to butamirate or any of its components
• Severe respiratory failure

Adverse effects

• Drowsiness
• Nausea
• Vomiting
• Rash
• Dizziness

Interactions

• CNS depressants may enhance the sedative effects of butamirate
• May interact with other cough suppressants

Precautions

• Use with caution in patients with a history of respiratory conditions
• Monitor patients for signs of sedation
• Consider potential for misuse in patients with a history of substance abuse

Pregnancy

Butamirate should only be used in pregnancy if clearly needed and after careful consideration of risks and benefits.

Breast-feeding

It is not known whether butamirate is excreted in human breast milk. Caution should be exercised when administering to breastfeeding women.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

Formulations

• Oral solution
• Tablets
• Syrup