DAFLON 500 MG

Indications

• Chronic venous insufficiency
• Varicose veins
• Hemorrhoids
• Lymphedema
• Diabetic microangiopathy

Dosage

Children: Refer to BNF for Children for specific dosing recommendations.

Adults: Refer to BNF for specific dosing recommendations.

Mechanism of action

Diosmin helps to maintain circulatory system structure and function, particularly vein strength and competence. Although its precise molecular mechanism has not been fully established, there is evidence suggesting that diosmin may bind to the aryl hydrocarbon receptor, with unclear clinical relevance to vascular function. Research also indicates that oral diosmin can influence the metabolism of noradrenaline in varicose veins, potentially benefiting vascular health.

Pharmacodynamics

Diosmin is classified as a venoactive drug that supports circulatory health through various actions on blood vessels. It enhances lymphatic drainage, improves microcirculation, and increases venous tone and elasticity. This drug has been shown to exert antioxidant activity, scavenging oxygen free radicals and reducing oxidative stress, as evidenced by decreased levels of biomarkers such as prostaglandins isoprostane precursors. Clinical studies have reported significant decreases in inflammatory markers like TNF alpha, VEGF-C, VEGF-A, IL-6, and FGF2 following diosmin therapy. Additionally, diosmin has been associated with reductions in edema and leg circumference in patients with chronic venous conditions and has shown potential benefits in glucose metabolism in diabetic disorders.

Pharmacokinetics

The pharmacokinetics of diosmin are not extensively detailed in the provided sources. However, it is known to be well absorbed from the gastrointestinal tract and undergoes extensive metabolism. The elimination half-life and specific metabolic pathways have not been established in the available literature.

Adverse effects

• Gastrointestinal disturbances
• Headache
• Dizziness
• Rash

Precautions

• Use with caution in patients with known hypersensitivity to diosmin or any of its excipients
• Patients with severe hepatic impairment should use diosmin with caution

Pregnancy

Diosmin should only be used in pregnancy if the potential benefit justifies the potential risk to the fetus, as safety during pregnancy has not been established.

Breast-feeding

Diosmin is excreted in breast milk; caution should be exercised when administering to breastfeeding women.

Storage

Store in a cool, dry place, away from direct sunlight and out of reach of children.

Formulations

• Tablets
• Capsules

Mechanism of action

Diosmin helps to maintain circulatory system structure and function, particularly vein strength and competence. The molecular mechanism of action of diosmin has not been established. Several resources indicate that diosmin binds to the aryl hydrocarbon receptor, however clinical relevance to vascular function is unknown. One study demonstrates that oral diosmin exerts effects on the in vitro metabolism of noradrenaline by varicose veins, potentially benefitting vascular health.

Pharmacodynamics

Diosmin is a venoactive drug supporting circulatory health through various actions on blood vessels; it supports lymphatic drainage and improves microcirculation while increasing venous tone and elasticity. For these reasons, diosmin is frequently taken by individuals with chronic venous disease to support vascular health and has been demonstrated to improve quality of life. In addition to the above effects, diosmin exerts antioxidant activity and scavenges oxygen free radicals, reducing levels of oxidative stress normally detected through biomarkers such as prostaglandins isoprostane precursors. In one clinical study, mean content of TNF alpha, VEGF-C, VEGF-A IL-6, in addition to FGF2 were decreased by after the therapy with diosmin; findings were statistically significant. Additionally, a decrease in edema and mean leg circumference of patients taking diosmin for three months was observed in a clinical study. Diosmin has been demonstrated to enhance the metabolism of glucose in diabetic disorders.