DAXOCOX 15 mg TABLETS FOR DOGS

Indications

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Acute pain

Dosage

Children: There is limited pediatric dosing information available for enflicoxib, therefore it is important to refer to the BNF for Children for appropriate dosing guidance.

Adults: The dosing of enflicoxib in adults typically depends on the specific condition being treated. It is important to refer to the BNF for precise dosing recommendations.

Mechanism of action

Enflicoxib selectively inhibits the COX-2 enzyme, which is responsible for the synthesis of prostaglandins that mediate inflammation, pain, and fever. By inhibiting COX-2, enflicoxib reduces the production of these inflammatory mediators, thereby alleviating pain and inflammation without significantly affecting COX-1, which is involved in maintaining gastric mucosal integrity.

Pharmacodynamics

The pharmacodynamic effects of enflicoxib include a reduction in pain and inflammation associated with various inflammatory conditions. It provides relief from symptoms of arthritis and has a favorable gastrointestinal safety profile compared to non-selective NSAIDs, as it spares COX-1 activity.

Pharmacokinetics

Enflicoxib is well absorbed following oral administration, with peak plasma concentrations occurring within 2 to 4 hours. It has a half-life that allows for once-daily dosing. The drug is extensively metabolized in the liver, primarily via cytochrome P450 enzymes, and is excreted mainly in urine. Its bioavailability may be affected by food intake.

Contra-indications

• Hypersensitivity to enflicoxib or any of its components
• Active peptic ulcer disease
• Severe heart failure
• History of gastrointestinal bleeding or perforation related to previous NSAID therapy
• Pregnancy

Adverse effects

• Gastrointestinal disturbances, including nausea and diarrhea
• Headache
• Dizziness
• Hypertension
• Renal impairment
• Hepatic enzyme elevations
• Skin rash or allergic reactions

Interactions

• Anticoagulants such as warfarin may increase bleeding risk
• Other NSAIDs may increase the risk of adverse effects
• Corticosteroids may increase the risk of gastrointestinal side effects
• ACE inhibitors may have reduced effectiveness
• Cytochrome P450 substrates may have altered metabolism

Precautions

• Use with caution in patients with renal impairment
• Monitor blood pressure regularly
• Consider the potential for gastrointestinal side effects
• Use caution in elderly patients or those with comorbidities

Pregnancy

Enflicoxib is contraindicated during pregnancy due to potential risks to the fetus.

Breast-feeding

It is not known if enflicoxib is excreted in human milk; caution should be exercised.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

Formulations

• Tablets
• Oral suspension