DECA-DURABOLIN 50 MG/ML

Indications

• Osteoporosis in postmenopausal women
• Muscle wasting conditions

Dosage

Adults: 50 mg every 3 weeks via deep intramuscular injection.

Mechanism of action

Nandrolone functions by modulating muscle remodeling in response to functional overload, which is critical for muscle growth. It alters morphological characteristics and gene expression related to muscle growth, including the regulation of cell cycle proteins that are involved in muscle hypertrophy. Specifically, nandrolone administration can decrease the induction of small muscle fibers and inhibit the expression of myogenic regulatory factors that are essential for muscle development.

Pharmacodynamics

As an anabolic steroid, nandrolone enhances protein synthesis and promotes positive nitrogen balance in the body. It has a high affinity for androgen receptors, leading to increased muscle mass and strength. Additionally, nandrolone has been noted to improve bone density, making it beneficial in the treatment of osteoporosis.

Pharmacokinetics

Nandrolone is administered via intramuscular injection, resulting in a slow release into the systemic circulation. It has a half-life that allows for less frequent dosing, typically every 3 weeks. The metabolism of nandrolone occurs primarily in the liver, with excretion mainly through the urine. The pharmacokinetic profile can be affected by individual patient factors such as hepatic and renal function.

Contra-indications

• Acute porphyrias
• Malignant disease
• Severe hepatic impairment
• Cardiac impairment
• Diabetes mellitus
• Epilepsy
• Hypertension
• Migraine
• Skeletal metastases

Adverse effects

• Clitoromegaly
• Dysphonia
• Hepatic disorders
• Hirsutism
• Hypertension
• Increased libido
• Nausea
• Oedema
• Skin reactions
• Sodium retention
• Decreased urine flow
• Virilism (with high doses, including voice changes - sometimes irreversible)

Interactions

• Nandrolone + Coumarins: Moderate (increases anticoagulant effect)
• Nandrolone + Phenindione: Moderate (increases anticoagulant effect)

Precautions

• Caution in patients with cardiac impairment
• Caution in patients with renal impairment (increased risk of fluid retention and heart failure)
• Inform patients about the risk of osteonecrosis of the jaw
• Patients should maintain good oral hygiene and report dental issues

Pregnancy

Nandrolone is contraindicated during pregnancy due to potential harm to the fetus.

Breast-feeding

The effects of nandrolone during breastfeeding are unknown; caution is advised.

Storage

Store in a cool, dry place, away from direct sunlight. Keep out of reach of children.

Formulations

• Nandrolone decanoate (deep intramuscular injection)

Mechanism of action

Functionally overloading rat soleus muscle by synergist ablation induces a rapid increase in mass. Muscle remodeling during the first week of overload is critical for the overload-induced growth. Anabolic steroid modulation of this overload-induced remodeling response is not well understood. The purpose of this study was to determine whether pretreatment with nandrolone decanoate, a clinically administered anabolic steroid, alters muscle morphology and gene expression related to muscle growth during the initiation of functional overload in the rat soleus muscle. Adult (5 mo) male Fisher 344 x Brown Norway rats were randomly assigned to control (Sham), 3-day functional overload (OV), nandrolone decanoate administration (ND), or 3-day functional overload with nandrolone decanoate administration (OV+ND) treatment groups. Morphologically, OV increased the percentage of small (361%) and large (150%) fibers and expanded the ECM 50%. ND administration decreased the 3-day OV induction of small fibers 51% and nuclei associated with the ECM 20%. ND administration also attenuated the induction of cell cycle regulator p21 (64%) and myogenin (37%) mRNAs after 3 days of overload. These data demonstrate that nandrolone decanoate pretreatment can alter morphological and cell cycle regulator expression related to muscle growth at the onset of functional overload. Anabolic-androgenic steroids (AASs) are widely abused by adolescents, although persistent AAS use can cause several adverse physical and mental effects, including drug dependence. The first aim of the present study was to study the action of nandrolone decanoate on dopaminergic and serotonergic activities in the brains of rats. In order to evaluate the anabolic or toxic effects of the dosing regimens used, selected peripheral effects were monitored as well. Male Wistar rats were treated for 2 weeks. Injections containing nandrolone (5 and 20 mg/kg, i.m.) or vehicle were given once daily, 5 days a week. The levels of dopamine (DA), 5-hydroxytryptamine (5-HT) and their metabolites were assayed from dissected brain regions 3 days after the last injection. Blood was collected for chemical assays before, after 1 week treatment and at decapitation. Both doses of nandrolone significantly increased the levels of 3,4-dihydroxyphenylacetic acid (DOPAC), a metabolite of DA in the cerebral cortex, and the higher dose of nandrolone increased the concentrations of 5-HT in the cerebral cortex compared with the vehicle. In addition, after nandrolone treatment, the levels of hemoglobin and erythrocytes increased, and reticulocyte levels decreased. The results suggest that nandrolone at supraphysiological doses, high enough to induce erythropoiesis, induces changes in the dopaminergic and serotonergic neuronal system in the brains of rats. These phenomena may account to some of the observed central stimulatory properties that have been reported following AAS abuse. Reverses catabolic processes and negative nitrogen balance by promoting protein anabolism and stimulating appetite if there is concurrently a proper intake of calories and proteins. /Anabolic steroids/ Antianemic: Anemias due to bone marrow failure: Increases production and urinary excretion of erythropoietin. Anemias due to deficient red cell production : Stimulates erythropoietin production and may have a direct action on bone marrow. Anemias associated with renal disease: increases hemoglobin and red blood cell volume. /Anabolic steroids/