DHEA-25

Indications

• Adrenal insufficiency
• Aging-related hormonal decline
• Sexual dysfunction
• Mood disorders
• Osteoporosis prevention

Dosage

Children: Refer to specific guidelines and clinical studies for dosing recommendations, as they can vary based on indication and patient characteristics.

Adults: Refer to specific guidelines and clinical studies for dosing recommendations, as they can vary based on indication and patient characteristics.

Mechanism of action

DHEA exerts its effects by being converted into androgens and estrogens in peripheral tissues. It acts on androgen and estrogen receptors, influencing various physiological processes. Additionally, DHEA may enhance the immune response, improve cognitive function, and promote muscle strength, although the exact pathways remain complex and not fully elucidated.

Pharmacodynamics

DHEA influences the hormonal balance in the body, potentially affecting mood, energy levels, and sexual function. It is thought to modulate neurotransmitter systems, including serotonin and dopamine pathways, contributing to its effects on mood and cognitive function. DHEA also plays a role in lipid metabolism and may have protective effects on cardiovascular health.

Pharmacokinetics

DHEA is rapidly absorbed following oral administration, with peak plasma concentrations occurring within 2-4 hours. It has a relatively short half-life of approximately 15-30 minutes. The hormone is metabolized primarily in the liver and is excreted in urine as sulfated and unconjugated metabolites. The bioavailability of DHEA can be affected by factors such as age, sex, and overall health status.

Contra-indications

• Hypersensitivity to dehydroepiandrosterone (DHEA) or any of its components
• Hormone-sensitive conditions (e.g., prostate cancer, breast cancer)

Adverse effects

• Acne
• Hair loss
• Increased hair growth (hirsutism)
• Mood changes
• Insomnia
• Headache
• Hypertension
• Changes in menstrual cycle
• Gastrointestinal disturbances

Interactions

• May interact with anticoagulants, leading to an increased risk of bleeding
• Can affect the metabolism of other hormones and drugs metabolized by the liver

Precautions

• Monitor for signs of hormonal imbalance
• Use with caution in patients with liver disease
• Caution in patients with a history of hormone-sensitive cancers
• Consult healthcare provider before use in the elderly

Pregnancy

The safety of dehydroepiandrosterone during pregnancy has not been established. It is recommended to avoid use during pregnancy.

Breast-feeding

Not recommended during breastfeeding due to unknown effects on the nursing infant.

Storage

Store in a cool, dry place away from light. Keep out of reach of children.

Formulations

• Oral tablets
• Capsules

Indications

• Adrenal insufficiency
• Inflammatory conditions
• Allergic reactions
• Autoimmune diseases
• Hormonal replacement therapy

Dosage

Children: Refer to clinical guidelines for specific dosing recommendations based on the condition being treated.

Adults: Refer to clinical guidelines for specific dosing recommendations based on the condition being treated.

Mechanism of action

Sterone hormones act primarily by binding to specific intracellular receptors, forming a hormone-receptor complex that translocates to the nucleus. Once in the nucleus, this complex binds to specific DNA sequences, leading to modulation of gene expression. This process results in alterations to protein synthesis that influence metabolic pathways, immune responses, and other cellular functions.

Pharmacodynamics

The pharmacodynamics of sterone hormones involve their effects on various bodily systems. These hormones can modulate inflammation, influence carbohydrate and protein metabolism, and regulate electrolyte balance. They exhibit a wide range of actions depending on the specific type of sterone, such as glucocorticoids, which primarily affect glucose metabolism and immune responses, or mineralocorticoids, which predominantly regulate sodium and potassium levels.

Pharmacokinetics

Sterone hormones are typically absorbed well when administered systemically, with peak plasma concentrations occurring within hours. They are extensively metabolized in the liver, where they can undergo various transformations leading to active or inactive metabolites. These hormones are primarily excreted via the kidneys. The half-lives can vary significantly among different sterones, affecting their duration of action and dosing frequency.

Pregnancy

The safety of sterone during pregnancy has not been established. It is advised to use caution and only if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

Sterone is excreted in breast milk. Caution should be exercised when administering to nursing mothers.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.