What it does
Montmorillonite is a natural clay used to treat various digestive issues.
Commonly used for: diarrhea, gastrointestinal disturbances
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:46:06 · updated 2026-03-23 04:31:11
About this medicine
Montmorillonite is a natural clay used to treat various digestive issues.
What it treats
- diarrhea
- gastrointestinal disturbances
How it works
Montmorillonite helps absorb excess fluids and toxins in the gut, which can relieve symptoms of diarrhea.
Who it's for
Adults and children experiencing diarrhea or stomach upset.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: montmorillonite
BNF-referencedMontmorillonite is a naturally occurring clay mineral that is part of the smectite group. It is primarily composed of aluminum silicate and is known for its ability to absorb water and swell, which makes it useful in various medical applications, particularly in the treatment of gastrointestinal disorders. Its adsorption properties allow it to bind toxins and other substances in the gut, thereby facilitating their excretion.
Indications
- Diarrhea
- Gastrointestinal upset
- Toxin adsorption
- Acid reflux
Dosage
Children: Refer to the BNF for Children for specific pediatric dosing recommendations, as these will depend on the child's age and weight.
Adults: Refer to the BNF for specific dosing guidelines, as the appropriate dosage may vary based on the condition being treated.
Mechanism of action
The mechanism of action of montmorillonite is not fully understood. However, it has been postulated that it may inhibit certain enzymes, as in vitro studies have shown that low concentrations of bentonite can suppress the activity of human leukocyte elastase, an enzyme that plays a role in the destruction of microorganisms by neutrophils.
Pharmacodynamics
Montmorillonite exhibits its pharmacological effects primarily through its adsorption capacity. It binds to various substances in the gastrointestinal tract, including toxins, pathogens, and excess gastric acid, which can help alleviate symptoms associated with gastrointestinal disorders. Its swelling properties also enhance its surface area, increasing its efficacy as an adsorbent.
Pharmacokinetics
Montmorillonite is not significantly absorbed systemically due to its large particle size and structure. It acts locally within the gastrointestinal tract, where it binds to and facilitates the excretion of various substances. Its effects are primarily seen within the gut, and it does not undergo metabolism or excretion in the traditional sense since it is not absorbed.
Pregnancy
There is limited data on the safety of montmorillonite during pregnancy. Consult a healthcare provider for guidance.
Breast-feeding
Limited information is available on the excretion of montmorillonite in human milk. Consult a healthcare provider for guidance.
Storage
Store in a cool, dry place, away from direct sunlight.
Formulations
- Powder
- Capsules
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: montmorillonite
PubChem CID 71586775Molecular formula: Al2H2O12Si4
Mechanism of action
The mechanism by which bentonite increases susceptibility is unknown. /Investigators/ however, postulated that enzyme inhibition by bentonite may be a factor, based on their in vitro observation that a low concentration of bentonite can totally suppress the activity of human leukocyte elastase, an enzyme important in the destruction of microorganisms phagocytized by neutrophils.
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.