DINZINC DT TABLETS
ZINC SULFATE MONOHYDRATE
Ask about this medicine
Answers come only from this medicine's registration record, BNF monograph and interaction data - not medical advice.
Hard to find? We help patients in Kenya source rare medicines. We don't sell or dispense medicines - licensed pharmacies do.
Source this medicineRegistration & product details
Source: Pharmacy and Poisons Board · fetched 2026-01-28 19:23:11 · updated 2026-08-03 02:09:32
Clinical monograph: Zincsulfate
BNF-referencedZinc sulfate is a vital trace element crucial for various biological functions, including enzyme activity and immune function. It is used primarily to treat zinc deficiency, which can arise from malnutrition, certain medical conditions, and excessive zinc loss. Common indications for zinc supplementation include inflammatory bowel disease, malabsorption syndromes, and conditions like Wilson's disease and acrodermatitis enteropathica that result in impaired zinc absorption.
Indications
- Zinc deficiency
- Wilson's disease
- Acrodermatitis enteropathica
- Malabsorption syndromes
- Inflammatory bowel disease
Dosage
Children: For children, the dosage varies by weight: Neonates should receive 1 mg/kg daily, while those weighing up to 10 kg receive 22.5 mg daily. For children weighing 10–30 kg, the dose is typically 22.5 mg 1–3 times a day, and for those over 31 kg, 45 mg 1–3 times a day, adjusted as necessary.
Adults: For adults, the recommended dose is 45 mg of elemental zinc 1–3 times daily, adjusted as necessary and taken after food.
Mechanism of action
Zinc sulfate acts by participating in numerous enzymatic reactions and plays a significant role in immune system function. It is a cofactor for over 300 enzymes, including those involved in DNA synthesis, cell division, and protein synthesis. Zinc also stabilizes cell membranes and is essential for the proper functioning of the immune system.
Pharmacodynamics
Zinc sulfate enhances immune responses, promotes wound healing, and influences taste and smell. It plays a critical role in cellular metabolism and is necessary for the activity of various enzymes. Zinc deficiency can lead to impaired immune function, increased susceptibility to infections, and delayed wound healing.
Pharmacokinetics
Zinc sulfate is readily absorbed from the gastrointestinal tract, with bioavailability varying based on dietary composition. Peak plasma concentrations typically occur within 2 to 3 hours after oral administration. Zinc is distributed throughout the body, with significant accumulation in the muscle, bone, and the liver. The kidneys primarily excrete zinc, and its half-life in the body is approximately 2 to 4 hours.
Adverse effects
- Gastrointestinal adverse effects
- Copper deficiency
- Reduced immunity
- Anaemia
- Genitourinary complications
Precautions
- Use higher doses short-term due to the risk of gastrointestinal adverse effects
- Monitor for copper deficiency and reduced immunity with long-term use
Pregnancy
Zinc sulfate is generally considered safe during pregnancy and is sometimes recommended for supplementation.
Breast-feeding
Zinc sulfate is also considered safe during breastfeeding, as zinc is an essential nutrient for both mother and infant.
Storage
Store in a cool, dry place away from light.
Formulations
- Effervescent tablet 125 mg (45 mg zinc)
- Capsule 125 mg (45 mg zinc)
- Oral solution 500 micrograms/10ml
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.