What it does
Maduramycin is a medicine used to treat certain infections in animals, particularly in veterinary settings.
Commonly used for: infections in animals
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:33:24 · updated 2026-07-20 11:07:35
About this medicine
Maduramycin is a medicine used to treat certain infections in animals, particularly in veterinary settings.
What it treats
- infections in animals
How it works
Maduramycin works by stopping the growth of harmful bacteria in the body.
Who it's for
This medicine is meant for use in animals, not for people.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: maduramycin
BNF-referencedMaduramycin is an antibiotic belonging to the polyether class, primarily used in veterinary medicine to treat coccidiosis in livestock. It is derived from the fermentation of the Actinoplanes species. Maduramycin exerts its effects by disrupting the normal function of ion channels, particularly sodium channels, which plays a crucial role in the physiology of protozoan parasites.
Indications
- Coccidiosis in livestock
- Treatment of Eimeria infections
Dosage
Children: Refer to specific veterinary guidelines or the manufacturer's recommendations for dosage.
Adults: Refer to specific veterinary guidelines or the manufacturer's recommendations for dosage.
Mechanism of action
Maduramycin acts by binding to the intracellular domain of sodium channels, resulting in disruption of sodium ion transport across the cell membrane. This leads to altered membrane potential and ultimately affects the viability and reproduction of coccidia, the protozoan parasites responsible for coccidiosis.
Pharmacodynamics
Maduramycin exhibits a potent coccidiostatic effect, inhibiting the growth and reproduction of various Eimeria species. Its activity is dose-dependent, and it is effective against both the sexual and asexual phases of the coccidian life cycle. The drug displays a high margin of safety in the target species, with a low potential for toxicity when used as directed.
Pharmacokinetics
Maduramycin is characterized by rapid absorption and distribution in animal tissues following administration. The drug undergoes significant metabolism, primarily in the liver, leading to various metabolites that may also exhibit pharmacological activity. Excretion occurs mainly via the feces, with minimal renal elimination. The half-life and bioavailability can vary based on the species and formulation used.
Pregnancy
There is limited data on the use of maduramycin in pregnancy. It should be used only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is not known whether maduramycin is excreted in human milk. Caution is advised when administering to breastfeeding women.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: maduramycin
PubChem CID 14782628Molecular formula: C47H83NO17
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.