EMANZEN FORTE TABLETS

Indications

• Chronic pain conditions
• Postoperative swelling
• Traumatic injuries
• Sinusitis
• Bronchitis

Dosage

Children: Refer to the BNF for Children for appropriate dosing information.

Adults: Refer to the BNF for appropriate dosing information.

Mechanism of action

Serratiopeptidase exerts its effects primarily through the breakdown of proteins and the modulation of inflammatory processes. It acts by hydrolyzing peptide bonds in proteins, which can lead to the dissolution of dead or damaged tissue and the reduction of inflammatory mediators, thus attenuating pain and swelling. This enzymatic action helps to improve tissue repair and healing.

Pharmacodynamics

The pharmacodynamics of serratiopeptidase involve its ability to modulate inflammation and pain through its proteolytic activity. By breaking down inflammatory mediators and promoting tissue healing, serratiopeptidase can enhance recovery from various inflammatory conditions. Its analgesic properties may also be attributed to the reduction of bradykinin and other inflammatory substances that contribute to pain.

Pharmacokinetics

Serratiopeptidase is absorbed in the gastrointestinal tract, with its bioavailability influenced by the presence of food. Once in the bloodstream, it distributes to tissues where it exerts its proteolytic effects. The enzyme is metabolized primarily in the liver, and its elimination half-life is variable, depending on individual patient factors. Renal function may also play a role in the clearance of serratiopeptidase and its metabolites.

Pregnancy

There is insufficient evidence regarding the safety of serratiopeptidase during pregnancy. Consult healthcare professionals before use.

Breast-feeding

Limited data are available on the excretion of serratiopeptidase in breast milk. Caution is advised when administering to nursing mothers.

Storage

Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.

Formulations

• {'name': 'Serratiopeptidase tablet', 'strength': '10 mg', 'route': 'oral'}
• {'name': 'Serratiopeptidase capsule', 'strength': '20 mg', 'route': 'oral'}