What it does
Pyritinol is a medication that is sometimes used to help improve cognitive function and memory.
Commonly used for: cognitive impairment, memory disorders
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:53:22 · updated 2026-03-23 04:38:28
About this medicine
Pyritinol is a medication that is sometimes used to help improve cognitive function and memory.
What it treats
- cognitive impairment
- memory disorders
How it works
Pyritinol works by enhancing blood flow to the brain and improving nerve function, which may help with thinking and memory.
Who it's for
It is generally used for adults who are experiencing issues with memory or cognitive skills.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: pyritinol
BNF-referencedPyritinol is a synthetic derivative of vitamin B6 (pyridoxine), primarily used as a nootropic agent. It has been investigated for its potential benefits in cognitive enhancement and as an adjunct therapy in neurological conditions. Pyritinol is known to enhance cerebral metabolism and improve blood circulation in the brain, thereby supporting cognitive functions.
Indications
- Cognitive impairment
- Alzheimer's disease
- Dementia
- Cerebral ischemia
- Peripheral neuropathy
Dosage
Children: For paediatric patients, dosing must be determined by a healthcare professional and may vary based on the condition being treated. Refer to the BNF for Children for specific guidelines.
Adults: The typical adult dose is 400 mg to 600 mg per day, administered in divided doses.
Mechanism of action
Pyritinol is believed to enhance neuronal metabolism by increasing the uptake of glucose and oxygen in the brain. It may also modulate neurotransmitter levels, particularly acetylcholine, which is crucial for learning and memory processes. Additionally, it has antioxidant properties that may protect neurons from oxidative stress.
Pharmacodynamics
Pyritinol exhibits nootropic effects, which can lead to improvements in cognitive function, memory, and attention. Its influence on cerebral blood flow and metabolism can enhance neuronal activity and synaptic plasticity, which are essential for learning and memory processes.
Pharmacokinetics
Pyritinol is well absorbed following oral administration. It is metabolized in the liver, and its metabolites are primarily excreted via the kidneys. The half-life of pyritinol is approximately 6 to 8 hours, necessitating multiple doses throughout the day for sustained effects.
Adverse effects
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Allergic reactions
Precautions
- Use with caution in patients with hepatic impairment
- Monitor for gastrointestinal side effects
Pregnancy
There is limited data on the use of pyritinol in pregnancy, and it should only be used if clearly needed.
Breast-feeding
It is not known whether pyritinol is excreted in human milk, caution is advised.
Storage
Store in a cool, dry place away from direct light.
Formulations
- Tablets
- Injectable solutions
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: pyritinol
PubChem CID 14190Molecular formula: C16H20N2O4S2
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.