What it does
Ebastine is an antihistamine used to relieve allergy symptoms.
Commonly used for: allergic rhinitis (hay fever), urticaria (hives)
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Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:38 · updated 2026-09-29 04:33:03
About this medicine
Ebastine is an antihistamine used to relieve allergy symptoms.
What it treats
- allergic rhinitis (hay fever)
- urticaria (hives)
How it works
Ebastine helps reduce allergy symptoms by blocking the action of histamine, a substance in the body that causes allergic reactions.
Who it's for
Ebastine is suitable for adults and children over 12 years who experience allergies.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: ebastin
BNF-referencedEbastine is a second-generation antihistamine primarily used for the relief of symptoms associated with allergic conditions. It is effective in managing allergic rhinitis and urticaria, providing symptomatic relief without the sedative effects commonly associated with first-generation antihistamines.
Indications
- Allergic rhinitis
- Urticaria
Dosage
Children: Refer to BNF for Children for specific dosing guidelines.
Adults: Refer to BNF for specific dosing guidelines.
Mechanism of action
Ebastine functions as a selective antagonist of the histamine H1 receptor, effectively blocking the action of histamine, a key mediator in allergic responses. This action leads to a decrease in symptoms such as itching, sneezing, and nasal congestion associated with allergies.
Pharmacodynamics
The pharmacodynamic properties of ebastine include its ability to selectively inhibit the binding of histamine to H1 receptors, thus preventing the activation of downstream signaling pathways that contribute to allergic symptoms. This selectivity also results in a lower incidence of central nervous system side effects compared to first-generation antihistamines.
Pharmacokinetics
Ebastine is well absorbed following oral administration, with peak plasma concentrations typically occurring within 1 to 2 hours. It undergoes extensive first-pass metabolism, primarily to its active metabolite, carebastine, which contributes to its antihistaminic effect. The elimination half-life of ebastine is approximately 15 hours, allowing for once-daily dosing.
Adverse effects
- Drowsiness
- Headache
- Dry mouth
- Fatigue
- Nausea
Precautions
- Caution in patients with liver impairment
- Use with caution in patients with a history of seizures
Pregnancy
There is limited data on the use of ebastine in pregnancy. It should be used only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is unknown whether ebastine is excreted in human milk. Caution should be exercised when administering to breastfeeding women.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Formulations
- Tablets
- Oral suspension
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: ebastin
PubChem CID 3191Molecular formula: C32H39NO2
Mechanism of action
Ebastine is a second-generation antihistamine that acts as a selective histamine H1-receptor antagonist to relieve allergic symptoms.
Biological pathways
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.