EUMOVATE OINTMENT

Indications

• Dermatitis
• Eczema
• Psoriasis
• Allergic reactions
• Inflammatory skin conditions

Dosage

Children: For children, the dosage of clobetasone should be determined by a healthcare professional, and it generally follows the same frequency as in adults. Refer to the BNF for Children for specific dosing guidelines.

Adults: The usual adult dosage of clobetasone is applied to the affected area two to three times daily. It should be used for the shortest duration necessary to control symptoms, usually not exceeding four weeks of continuous use.

Mechanism of action

Topically applied clobetasone is thought to bind with cytoplasmic receptors in the dermal and intradermal cells, inducing inhibitory proteins that decrease the activity of prostaglandins, kinins, histamine, liposomal enzymes, and other endogenous mediators of inflammation. It inhibits the migration of macrophages and leukocytes into inflamed skin areas by reversing vascular dilation and permeability, resulting in decreased erythema, edema, and pruritus.

Pharmacodynamics

Clobetasone, like other topical corticosteroids, is a synthetic derivative of cortisone. It produces anti-inflammatory, antiproliferative, immunosuppressive, and vasoconstrictor effects when applied to the skin, leading to significant reduction in symptoms associated with inflammatory skin conditions.

Pharmacokinetics

Clobetasone is primarily absorbed through the skin when applied topically. Its systemic absorption is relatively low, which limits its potential side effects compared to systemic corticosteroids. The pharmacokinetics may vary based on the application site, formulation, and integrity of the skin barrier. Metabolism occurs mainly in the liver, and elimination is primarily via urine.

Contra-indications

• Hypersensitivity to clobetasone or any of its excipients
• Untreated cutaneous infections
• Rosacea
• Perioral dermatitis
• Acne vulgaris

Adverse effects

• Skin atrophy
• Striae
• Telangiectasia
• Hypopigmentation
• Systemic absorption leading to adrenal suppression
• Folliculitis
• Contact dermatitis

Precautions

• Use with caution in patients with a history of hypersensitivity to other corticosteroids
• Avoid prolonged use on sensitive areas such as the face and intertriginous areas
• Monitor for signs of systemic absorption, especially in children

Pregnancy

Clobetasone can be used in pregnancy if the benefits outweigh the risks. Long-term use should be avoided.

Breast-feeding

Clobetasone is excreted in breast milk, caution is advised when using in breastfeeding mothers.

Storage

Store at room temperature, away from direct sunlight and moisture. Keep out of reach of children.

Formulations

• Cream
• Ointment
• Lotions

Mechanism of action

Topically applied clobeyasone are thought to bind with cytoplasmic receptors in the dermal and intradermal cells and to induce inhibitory proteins, thus leading to decreased activity of prostaglandins, kinins, histamine, liposomal enzymes and other endogenous mediators of inflammation. Topical corticosteroids inhibit the migration of macrophages and leukocytes into areas of inflamed skin by reversing vascular dilation and permeability, resulting in decreased erythema, edema and pruritus.

Pharmacodynamics

Topical corticosteroid like clobetasone are synthetic derivatives of cortisone which produce anti-inflammatory, antiproliferative, immunosuppressive and vasoconstrictor effects when applied to the skin.