Facid HC Cream
Fusidic AcidHydrocortison Acetate
What it does
Acidhydrocortison is a type of medication used to reduce inflammation and suppress the immune system.
Commonly used for: inflammation, allergic reactions, autoimmune conditions
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Source: Pharmacy and Poisons Board · fetched 2026-08-27 13:11:23 · updated 2026-10-20 02:09:32
About acidhydrocortison
Acidhydrocortison is a type of medication used to reduce inflammation and suppress the immune system.
What it treats
- inflammation
- allergic reactions
- autoimmune conditions
How it works
It works by decreasing the body's immune response and reducing swelling.
Who it's for
This medication is typically prescribed for people with conditions that cause inflammation or an overactive immune system.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About fusidic
Fusidic is an antibiotic used to treat bacterial infections.
What it treats
- skin infections
- eye infections
- bacterial infections (general)
How it works
Fusidic works by stopping the growth of bacteria, helping to clear up infections.
Who it's for
Fusidic is for people with infections caused by bacteria.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: acidhydrocortison
Acid hydrocortisone, commonly known as hydrocortisone, is a corticosteroid medication used to treat various inflammatory and autoimmune conditions. It mimics the action of cortisol, a steroid hormone produced by the adrenal glands. Hydrocortisone is effective in reducing inflammation, suppressing the immune response, and managing symptoms associated with conditions such as allergies, asthma, and certain types of arthritis.
Indications
- Adrenal insufficiency
- Allergic reactions
- Autoimmune disorders
- Chronic inflammatory conditions
- Dermatological diseases
- Asthma exacerbations
- Rheumatoid arthritis
- Ulcerative colitis
Dosage
Children: Refer to established clinical guidelines for dosing; individual dosing may vary based on condition and response.
Adults: Refer to established clinical guidelines for dosing; individual dosing may vary based on condition and response.
Mechanism of action
Hydrocortisone exerts its effects by binding to glucocorticoid receptors in the cytoplasm of target cells. This receptor-ligand complex translocates to the nucleus, where it regulates the expression of genes involved in inflammation and immune response. It inhibits the production of pro-inflammatory cytokines and mediators, stabilizes cell membranes, and decreases the migration of leukocytes to sites of inflammation.
Pharmacodynamics
The pharmacodynamic effects of hydrocortisone include anti-inflammatory, immunosuppressive, and metabolic actions. Its anti-inflammatory properties are attributed to the inhibition of phospholipase A2 and the subsequent reduction of arachidonic acid, leading to a decrease in the synthesis of prostaglandins and leukotrienes. It also influences glucose metabolism, protein metabolism, and fat distribution.
Pharmacokinetics
Hydrocortisone is well-absorbed following oral administration, with its bioavailability ranging from 60% to 100%. It has a high volume of distribution and is extensively metabolized in the liver, primarily through conjugation to form inactive metabolites. The elimination half-life averages 1.5 to 2 hours, and it is excreted mainly in the urine. Renal impairment may affect the clearance of hydrocortisone.
Contra-indications
- Systemic fungal infections
- Hypersensitivity to hydrocortisone or any of its components
- Live vaccines in immunosuppressed patients
Adverse effects
- Increased risk of infections
- Hyperglycemia
- Hypertension
- Osteoporosis
- Cushing's syndrome
- Gastrointestinal perforation
- Mood changes
- Adrenal suppression
- Skin thinning
Interactions
- Non-steroidal anti-inflammatory drugs (NSAIDs) - increased risk of gastrointestinal side effects
- Anticoagulants - altered effects of anticoagulants
- Diuretics - risk of hypokalemia
- Vaccines - decreased response to live vaccines
Precautions
- Use with caution in patients with cardiovascular disease
- Monitor for signs of infection
- Adjust doses in patients with hepatic or renal impairment
- Taper off therapy to prevent adrenal insufficiency
Pregnancy
Hydrocortisone is classified as category C. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
Hydrocortisone is excreted in breast milk. Caution should be exercised when administering to nursing mothers.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Formulations
- Topical cream
- Topical ointment
- Oral tablets
- Injectable solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: fusidic
Fusidic acid is a steroid antibiotic primarily used to treat bacterial infections, particularly those caused by Staphylococcus aureus. It is often employed in the treatment of skin infections, such as impetigo and infected dermatitis, as well as in some cases of osteomyelitis and endocarditis. Fusidic acid works by inhibiting bacterial protein synthesis, which is essential for the growth and replication of bacteria.
Indications
- Bacterial skin infections
- Impetigo
- Infected dermatitis
- Osteomyelitis
- Endocarditis
Dosage
Children: Refer to BNF for Children for appropriate dosing recommendations.
Adults: Refer to specific guidelines for dosing based on the condition being treated.
Mechanism of action
Fusidic acid exerts its antibacterial effect by inhibiting bacterial protein synthesis. It binds to the elongation factor G (EF-G) in bacteria, preventing the translocation step during protein synthesis. This action effectively halts the production of proteins necessary for bacterial growth, leading to cell death.
Pharmacodynamics
Fusidic acid demonstrates time-dependent killing against susceptible bacteria. Its antibacterial spectrum includes gram-positive organisms, especially staphylococci. The drug's efficacy is influenced by the concentration at the site of infection and the duration of exposure, with higher concentrations generally leading to greater antibacterial activity.
Pharmacokinetics
Fusidic acid is well absorbed when administered orally, with peak plasma concentrations occurring within one to two hours. It is extensively protein-bound, primarily to albumin. The drug is metabolized in the liver and has a relatively long half-life of approximately 6 to 8 hours, allowing for less frequent dosing. The majority of the drug is excreted in the bile, with a minor amount appearing in the urine.
Contra-indications
- Hypersensitivity to fusidic acid or any of its components
- Severe liver impairment
Adverse effects
- Nausea
- Vomiting
- Diarrhea
- Rash
- Hepatotoxicity
- Jaundice
- Thrombocytopenia
Interactions
- May interact with anticoagulants such as warfarin, enhancing their effects
- Co-administration with statins may increase the risk of myopathy
- Potential interaction with cyclosporine, leading to increased plasma levels of cyclosporine
Precautions
- Use with caution in patients with liver disease
- Monitor liver function tests in prolonged therapy
- Evaluate for signs of allergic reactions
- Consider the potential for drug interactions, particularly with hepatic enzyme inducers or inhibitors
Pregnancy
Fusidic acid is classified as category C. It should only be used if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
Fusidic acid is excreted in breast milk. Caution is advised when administering to breastfeeding mothers.
Storage
Store at room temperature, away from light and moisture. Keep out of reach of children.
Formulations
- Topical cream
- Topical ointment
- Oral tablets
- Intravenous injection
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.
- FUCIPHAM · Aurochem Pharmaceuticals
- FUSIBRAN · Brawn Laboratories
- FUSIN · Lincoln Pharmaceuticals
- FUZI-SK · S Kant Healthcare
- Fusibact · Jamjoom Pharmaceuticals
- Fusizon · Pharaonia Pharmaceutical