FEBRICOL TABLETS
PARACETAMOLPSEUDOEPHEDRINE HCLCHLOPHENIRAMINE MALEATE
What it does
Chlorpheniramine is an antihistamine that helps relieve allergy symptoms.
Commonly used for: allergic rhinitis (hay fever), nasal allergies, itchy or watery eyes, runny nose
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 22:08:12 · updated 2026-03-23 04:53:21
About hclchlopheniramine
Chlorpheniramine is an antihistamine that helps relieve allergy symptoms.
What it treats
- allergic rhinitis (hay fever)
- nasal allergies
- itchy or watery eyes
- runny nose
How it works
It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Who it's for
It is suitable for adults and children who need relief from allergy symptoms.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About paracetamolpseudoephedrine
Paracetamol and pseudoephedrine is a combination medicine used to relieve pain and reduce fever, as well as to relieve nasal congestion.
What it treats
- pain relief
- fever reduction
- nasal congestion (stuffy nose)
How it works
Paracetamol works by blocking pain signals in the brain and lowering fever, while pseudoephedrine helps to shrink swollen blood vessels in the nasal passages to ease breathing.
Who it's for
This medicine is suitable for adults and children over a certain age who need relief from pain, fever, and nasal congestion.
Cautions
- • Do not use if you have a severe liver disease.
- • Use with caution if you have high blood pressure or heart problems.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: hclchlopheniramine
Chlorpheniramine is an antihistamine that is commonly used to relieve symptoms of allergy, hay fever, and the common cold. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Chlorpheniramine is primarily used for its sedative properties and to alleviate sneezing, runny nose, and itching.
Indications
- Allergic rhinitis
- Hay fever
- Urticaria
- Common cold symptoms
Dosage
Children: Refer to the BNF for Children for appropriate dosing guidelines.
Adults: Refer to the BNF for appropriate dosing guidelines.
Mechanism of action
Chlorpheniramine is a first-generation antihistamine that exerts its effects by competitively antagonizing the H1 histamine receptors. This prevents histamine from binding to its receptor, thereby reducing the symptoms of allergic reactions. Additionally, it can cross the blood-brain barrier, leading to its sedative effects.
Pharmacodynamics
The pharmacodynamic effects of chlorpheniramine include its ability to decrease vascular permeability, reduce edema, and alleviate the symptoms of allergic rhinitis and urticaria. Its sedative effects are due to central nervous system penetration, which can lead to drowsiness. The onset of action typically occurs within 1 hour, and the duration of effect can last up to 12 hours.
Pharmacokinetics
Chlorpheniramine is well absorbed from the gastrointestinal tract. It undergoes hepatic metabolism, with its metabolites excreted primarily in the urine. The elimination half-life is approximately 20 hours, but this can vary based on individual metabolic differences. The drug is also subject to first-pass metabolism.
Contra-indications
- Hypersensitivity to chlorpheniramine or any of its components
- Severe asthma or other severe respiratory conditions
- Narrow-angle glaucoma
- Prostatic hypertrophy
- Bladder neck obstruction
Adverse effects
- Drowsiness
- Dizziness
- Dry mouth
- Constipation
- Blurred vision
- Urinary retention
- Gastrointestinal disturbance
Interactions
- CNS depressants (e.g., alcohol, benzodiazepines) may enhance sedative effects
- MAO inhibitors can prolong and intensify the anticholinergic effects
- Anticholinergic agents may increase the risk of adverse effects
Precautions
- Use caution in patients with cardiovascular disease
- Caution in elderly patients due to increased sensitivity to anticholinergic effects
- Avoid use in patients with a history of seizures
- Monitor for signs of urinary retention
Pregnancy
Chlorpheniramine is classified as Category B. Animal studies have not shown any harm to the fetus, but there are no well-controlled studies in pregnant women. Use only if clearly needed.
Breast-feeding
Chlorpheniramine is excreted in breast milk. Caution is advised when administering to nursing mothers due to potential sedation in infants.
Storage
Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
Formulations
- Tablets
- Syrups
- Extended-release formulations
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: paracetamolpseudoephedrine
Paracetamol, also known as acetaminophen, is an analgesic and antipyretic agent used to relieve pain and reduce fever. Pseudoephedrine is a sympathomimetic amine that acts as a decongestant, relieving nasal congestion in conditions such as colds and sinusitis. The combination of paracetamol and pseudoephedrine is often used for the symptomatic treatment of colds and flu, providing both pain relief and nasal decongestion.
Indications
- Fever
- Mild to moderate pain
- Nasal congestion due to colds or sinusitis
- Symptomatic relief of cold and flu symptoms
Dosage
Children: Refer to the BNF for Children for appropriate dosing.
Adults: Refer to the BNF or product-specific guidelines for appropriate dosing.
Mechanism of action
Paracetamol exerts its analgesic and antipyretic effects primarily through the inhibition of prostaglandin synthesis in the central nervous system and may also act peripherally to block pain impulse generation. Pseudoephedrine works by stimulating alpha-adrenergic receptors, leading to vasoconstriction of the nasal mucosa, which decreases nasal congestion. It may also have mild stimulant effects on the central nervous system.
Pharmacodynamics
Paracetamol demonstrates a ceiling effect for analgesia, meaning that increasing the dose beyond a certain point does not enhance its analgesic effects. It is well absorbed from the gastrointestinal tract, and its peak plasma concentration is reached within 30 to 60 minutes after oral administration. Pseudoephedrine's decongestant effects typically last for 4 to 6 hours, as it is absorbed quickly and has a direct action on nasal blood vessels.
Pharmacokinetics
Paracetamol is metabolized primarily in the liver, with a small percentage excreted unchanged in the urine. Its half-life is approximately 2 to 3 hours in healthy adults. Pseudoephedrine has a half-life of about 5 to 8 hours and is also metabolized in the liver, with the majority excreted unchanged in the urine. Factors such as renal function and age can influence the pharmacokinetic parameters of both drugs.
Contra-indications
- Hypersensitivity to paracetamol or pseudoephedrine
- Severe hypertension
- Severe coronary artery disease
- Hyperthyroidism
- Concurrent use of monoamine oxidase inhibitors (MAOIs)
Adverse effects
- Nausea
- Vomiting
- Rash
- Dizziness
- Headache
- Insomnia
- Tachycardia
- Hypertension
- Dry mouth
Interactions
- Increased risk of hepatotoxicity when used with alcohol
- May enhance the effects of other sympathomimetic agents
- May reduce the antihypertensive effects of beta-blockers and other antihypertensive medications
- Can interact with anticoagulants, increasing the risk of bleeding
Precautions
- Use with caution in patients with liver impairment
- Use with caution in patients with cardiovascular disorders
- Caution in patients with a history of substance abuse
- Avoid prolonged use without consultation
Pregnancy
Paracetamol is generally considered safe in pregnancy when used as directed, but pseudoephedrine should be used with caution due to potential effects on fetal blood flow.
Breast-feeding
Paracetamol is usually safe during breastfeeding. Pseudoephedrine may reduce milk supply and should be used with caution.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
Formulations
- Tablets
- Liquid preparations
- Effervescent tablets
- Syrups
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.