FIBROSAL 50MG/G CREAM

Indications

• Musculoskeletal pain
• Arthritis
• Tendonitis
• Sprains and strains
• Back pain

Dosage

Children: Refer to BNF for Children for appropriate dosing in children.

Adults: Apply to the affected area 3 to 4 times daily as needed. Do not exceed the recommended dose.

Mechanism of action

Counter-irritation is thought to be effective at alleviating musculoskeletal pain as the irritation of the sensory nerve endings alters or offsets pain in the underlying muscle or joints that are served by the same nerves. When applied topically, methyl salicylate penetrates the skin and underlying tissues where it reversibly inhibits cyclooxygenase enzymes, preventing the production of inflammatory mediators such as prostaglandin and thromboxane A2.

Pharmacodynamics

Methyl salicylate relieves musculoskeletal pain in muscles, joints, and tendons by causing irritation and reddening of the skin due to dilated capillaries and increased blood flow. It is pharmacologically similar to aspirin and other NSAIDs, primarily acting as a rubefacient and skin irritant. The counter-irritation effect is believed to produce a soothing sensation of warmth.

Pharmacokinetics

Methylsalicylate is absorbed through the skin, and its effects are localized to the site of application. The ester is metabolized in the liver, where it is hydrolyzed to salicylic acid, which can contribute to its analgesic effects. The elimination half-life is variable and can be influenced by the route of administration and individual patient factors.

Adverse effects

• Skin irritation
• Burning sensation
• Allergic reactions
• Rash

Precautions

• Avoid contact with eyes and mucous membranes
• Do not apply to broken or irritated skin
• Use with caution in patients with a history of allergic reactions to salicylates
• Not recommended for use in children without medical advice

Pregnancy

Methylsalicylate should be used during pregnancy only if clearly needed. The potential risks and benefits must be assessed by a healthcare provider.

Breast-feeding

It is not known whether methylsalicylate is excreted in human milk. Caution should be exercised when administering to nursing women.

Storage

Store in a cool, dry place away from light. Keep out of reach of children.

Formulations

• Topical ointment
• Topical cream
• Topical gel

Mechanism of action

Counter-irritation is thought to be effective at alleviating musculoskeletal pain as the irritation of the sensory nerve endings is thought to alter or offset pain in the underlying muscle or joints that are served by the same nerves. This is thought to mask the underlying musculoskeletal pain and discomfort. When applied topically, methyl salicylate is thought to penetrate the skin and underlying tissues where it reversibly inhibits cyclooxygenase enzyme and locally and peripherally prevents the production of inflammatory mediators such as prostaglandin and thromboxane A2.

Pharmacodynamics

Methyl salicylate relieve musculoskeletal pain in the muscles, joints, and tendons by causing irritation and reddening of the skin due to dilated capillaries and increased blood flow. It is pharmacologically similar to aspirin and other NSAIDs but as a topical agent it primarily acts as a rubefacient and skin irritant. Counter-irritation is believed to cause a soothing sensation of warmth.