FLEXILYF 600MG CAPSULE

Indications

• Skin aging and wrinkle reduction
• Joint pain and osteoarthritis
• Tendon and ligament injuries
• Bone health
• Wound healing

Dosage

Children: Refer to specific product guidelines or consult a healthcare professional for appropriate dosing based on the indication and formulation used.

Adults: Refer to specific product guidelines or consult a healthcare professional for appropriate dosing based on the indication and formulation used.

Mechanism of action

Collagen exerts its effects primarily by providing the necessary amino acids, such as glycine, proline, and hydroxyproline, that are crucial for the synthesis of new collagen in the body. It is thought to stimulate fibroblast proliferation, which leads to increased collagen production and improved tissue repair. Additionally, collagen may enhance the hydration of the skin and improve its elasticity.

Pharmacodynamics

Collagen supplementation may promote the synthesis of new collagen and improve the integrity of the extracellular matrix. This can lead to improved skin hydration, elasticity, and the reduction of wrinkles. In joint health, collagen may help reduce inflammation and pain, contributing to improved mobility and function. The effects can vary based on the source of collagen (bovine, porcine, marine) and the form of administration (powder, liquid, capsules).

Pharmacokinetics

After oral administration, collagen peptides are absorbed in the gastrointestinal tract and enter the bloodstream. They can be transported to various tissues where they may be incorporated into the extracellular matrix. The half-life of collagen peptides is relatively short, and they are metabolized in the liver and other tissues. The bioavailability of collagen can vary based on the formulation and the presence of other dietary components.

Adverse effects

• Allergic reactions
• Skin rash
• Itching
• Gastrointestinal disturbances
• Nausea

Precautions

• Use with caution in individuals with fish allergies if derived from fish sources
• Monitor for allergic reactions

Pregnancy

Collagen is generally considered safe during pregnancy, but consult a healthcare professional before use.

Breast-feeding

Collagen is likely safe during breastfeeding, but consult a healthcare professional before use.

Storage

Store in a cool, dry place, away from direct sunlight. Keep out of reach of children.

Formulations

• Powder
• Capsules
• Liquid

Indications

• Food allergies
• Malabsorption syndromes
• Enteral nutrition
• Postoperative recovery
• Infant formula for sensitive infants

Dosage

Children: Dosing in children should be determined based on clinical needs, age, and weight. Refer to specific product guidelines or consult a healthcare professional for appropriate dosing.

Adults: Specific dosing should be guided by clinical indications and product formulations, as hydrolysed products can vary widely. Consultation with clinical guidelines or a healthcare professional is recommended.

Mechanism of action

Hydrolysed proteins or nutrients increase bioavailability by breaking down larger macromolecules into smaller, more easily absorbed units, such as dipeptides and free amino acids. This process can stimulate various metabolic pathways and cellular functions, as smaller peptides can have specific biological activities.

Pharmacodynamics

The pharmacodynamics of hydrolysed products primarily involve the enhanced absorption and utilization of amino acids and peptides in the body. These smaller molecules can rapidly enter systemic circulation, leading to quicker physiological responses, such as protein synthesis and energy production. Additionally, some hydrolysed proteins may exert immunomodulatory effects, influencing immune responses.

Pharmacokinetics

The pharmacokinetics of hydrolysed substances can vary depending on the specific product and its formulation. Generally, hydrolysed products are rapidly absorbed in the gastrointestinal tract. The absorption rate is influenced by the size of the peptides and the presence of other nutrients. Once absorbed, these compounds are distributed throughout the body, where they can be utilized for various metabolic processes, including muscle repair and growth. The elimination of hydrolysed components occurs through metabolic pathways that process amino acids and peptides.

Pregnancy

The safety of hydrolysed products during pregnancy has not been fully established; consult healthcare professionals for guidance.

Breast-feeding

Consult a healthcare professional before use during breastfeeding, as safety is not well established.

Storage

Store in a cool, dry place, away from direct sunlight and moisture.