FLUCORT-SKIN 0.025%W/W CREAM

Indications

• Eczema
• Psoriasis
• Dermatitis
• Allergic skin reactions
• Lichen planus

Dosage

Children: For paediatric patients, dosage should be determined by a healthcare professional, considering the child's age, weight, and the specific condition being treated. Refer to the BNF for Children for specific dosing guidelines.

Adults: The dosage of fluocinolone varies based on the formulation and severity of the condition. It is typically applied as a thin layer to the affected area once or twice daily, as directed by a healthcare professional.

Mechanism of action

Fluocinolone binds to specific corticosteroid receptors in the cytoplasm of target cells, leading to the transcription of anti-inflammatory proteins and the repression of pro-inflammatory cytokines. This process ultimately results in a decrease in inflammation and an alteration of the immune response.

Pharmacodynamics

Fluocinolone exhibits strong anti-inflammatory and immunosuppressive effects. Its potency allows for effective management of conditions characterized by excessive inflammation. The drug helps to decrease the migration of leukocytes to sites of inflammation and inhibits the release of inflammatory mediators, thereby alleviating symptoms associated with inflammatory skin disorders.

Pharmacokinetics

Fluocinolone is absorbed through the skin when applied topically. The systemic absorption may vary depending on the formulation, the area of application, and the condition of the skin. Once absorbed, fluocinolone is metabolized in the liver and excreted primarily via urine. The half-life of fluocinolone is variable, influenced by factors such as the route of administration and individual patient characteristics.

Adverse effects

• skin irritation
• burning sensation
• dryness
• hypopigmentation
• striae
• telangiectasia
• folliculitis

Precautions

• Avoid use on broken skin
• Consider potential systemic absorption especially in large areas or under occlusion
• Caution in patients with diabetes or impaired adrenal function

Pregnancy

Fluocinolone is classified as Category C. Its use during pregnancy should be considered only if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

Fluocinolone is excreted in breast milk. Caution should be exercised when administering to nursing women, particularly on large areas of the skin.

Storage

Store below 25 degrees Celsius. Protect from light.

Formulations

• Topical cream
• Topical ointment
• Topical solution