What it does
Fungzole is used to treat fungal infections on the skin and in other areas of the body.
Commonly used for: fungal skin infections, athlete's foot (tinea pedis), ringworm (tinea corporis)
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Zambia Medicines Regulatory Authority · fetched 2026-03-12 00:07:32 · updated 2026-10-22 03:40:00
About this medicine
Fungzole is used to treat fungal infections on the skin and in other areas of the body.
What it treats
- fungal skin infections
- athlete's foot (tinea pedis)
- ringworm (tinea corporis)
How it works
Fungzole works by stopping the growth of fungi that cause infections.
Who it's for
This medication is for adults and children suffering from fungal infections.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: fungzole
Fungzole is an antifungal medication primarily used to treat fungal infections. It belongs to the class of azole antifungals, which work by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption leads to increased membrane permeability and ultimately results in cell death. Fungzole is commonly prescribed for various superficial and systemic fungal infections.
Indications
- Candidiasis (oral thrush, vaginal yeast infections)
- Aspergillosis
- Cryptococcosis
- Dermatophyte infections (e.g., ringworm)
- Fungal infections in immunocompromised patients
Dosage
Children: Refer to the BNF for Children for appropriate dosing guidelines based on age and weight.
Adults: Refer to specific clinical guidelines and the product's prescribing information for appropriate dosing regimens.
Mechanism of action
Fungzole exerts its antifungal effects primarily by inhibiting the enzyme lanosterol 14-alpha-demethylase, which is involved in the conversion of lanosterol to ergosterol. Ergosterol is crucial for maintaining fungal cell membrane integrity. The inhibition of this enzyme disrupts the fungal cell membrane, leading to cell lysis and death.
Pharmacodynamics
The pharmacodynamics of Fungzole involve its ability to inhibit fungal growth and reproduction. It shows fungistatic activity against many species of fungi at lower concentrations and can be fungicidal at higher concentrations. The drug's efficacy may vary depending on the type of fungus and its susceptibility to azole antifungals.
Pharmacokinetics
Fungzole is well-absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within a few hours of oral administration. It has a large volume of distribution, indicating extensive tissue binding. The drug is metabolized in the liver, primarily via cytochrome P450 enzymes, and has a half-life that allows for once-daily dosing in many cases. Excretion occurs primarily through urine and feces.
Pregnancy
Fungzole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a healthcare provider for further advice.
Breast-feeding
It is not known whether Fungzole is excreted in human milk. Caution should be exercised when administering to breastfeeding mothers.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.