GARDAL 10%

Indications

• Ascariasis
• Strongyloidiasis
• Hookworm infections
• Enterobiasis
• Trichuriasis
• Other helminthic infections

Dosage

Children: Refer to the BNF for Children for specific dosing information.

Adults: Refer to the BNF for specific dosing information.

Mechanism of action

Ricobendazole exerts its anthelmintic effect by binding to tubulin, thereby inhibiting microtubule formation. This disrupts the cytoskeleton of the parasite, impairing its ability to absorb glucose and leading to its eventual death. The drug's action interferes with mitosis and other cellular processes critical to the parasite's survival.

Pharmacodynamics

The pharmacodynamics of ricobendazole involve its ability to selectively target parasitic worms while showing minimal toxicity to the host. The drug's effects are dose-dependent, with higher concentrations leading to increased efficacy against a broader range of helminths. It has a rapid onset of action, providing effective relief from symptoms associated with parasitic infections.

Pharmacokinetics

Ricobendazole is absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations typically occurring within a few hours. It undergoes extensive metabolism in the liver, leading to the formation of active metabolites. The elimination half-life varies but generally supports the dosing regimen for effective therapeutic outcomes. Excretion occurs primarily via the urine and feces.

Pregnancy

There is limited data on the use of ricobendazole in pregnancy. It should only be used if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

There is no information available regarding the excretion of ricobendazole in human milk. Caution is advised when administering to nursing mothers.

Storage

Store at room temperature, away from moisture and heat. Keep out of reach of children.

Formulations

• {'formulation': 'Tablet', 'strength': '100 mg'}
• {'formulation': 'Suspension', 'strength': '50 mg/5 ml'}