GASTORAL TABLETS
AMINOSIDINE SULPHATE
What it does
Aminosidine is an antibiotic used to treat certain bacterial infections.
Commonly used for: bacterial infections, infections caused by specific bacteria
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:17:14 · updated 2026-08-03 04:17:42
About this medicine
Aminosidine is an antibiotic used to treat certain bacterial infections.
What it treats
- bacterial infections
- infections caused by specific bacteria
How it works
Aminosidine works by stopping the growth of bacteria, helping the body to fight off the infection.
Who it's for
This medication is for patients with infections caused by bacteria that are sensitive to aminosidine.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: aminosidine
BNF-referencedAminosidine, also known as paromomycin, is a broad-spectrum aminoglycoside antibiotic derived from the bacterium Streptomyces rimosus var. paromomycinus. It is primarily used to treat infections caused by susceptible strains of bacteria, particularly in cases where other antibiotics are ineffective. Its mechanism involves the inhibition of protein synthesis in bacteria, leading to cell death.
Indications
- Intestinal amebiasis
- Bacterial infections caused by susceptible strains
Dosage
Children: Refer to the BNF for Children for specific dosing guidelines.
Adults: Refer to the BNF for specific dosing guidelines.
Mechanism of action
Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. It interacts with the A site of the 30S ribosomal subunit, causing the production of defective polypeptide chains. The accumulation of these defective proteins ultimately results in bacterial death.
Pharmacodynamics
Paromomycin exhibits broad-spectrum antibacterial activity, with its action closely resembling that of neomycin. Its effectiveness is demonstrated both in vitro and in vivo, making it a valuable option for treating specific bacterial infections.
Pharmacokinetics
Aminosidine is poorly absorbed from the gastrointestinal tract when administered orally, which allows it to remain effective in the intestinal lumen. It is primarily excreted unchanged in the urine. Detailed pharmacokinetic data may vary based on the route of administration and patient factors.
Pregnancy
There is limited data on the use of aminosidine in pregnancy. Caution is advised, and it should only be used if the potential benefits outweigh the risks.
Breast-feeding
Aminosidine is excreted in breast milk. Caution is advised when administering to nursing mothers.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
Formulations
- Injection
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: aminosidine
PubChem CID 165580Molecular formula: C23H45N5O14
Mechanism of action
Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.
Pharmacodynamics
Paromomycin is a broad spectrum aminoglycoside antibiotic produced by <i>Streptomyces rimosus</i> var. paromomycinus. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin.
Biological pathways
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.