GCP ANTISEPTIC LIQUID

Indications

• Control of ectoparasites in livestock
• Control of fleas and ticks in pets
• Treatment of sarcoptic mange

Dosage

Children: Refer to the BNF for Children for specific dosing information tailored to paediatric patients.

Adults: Refer to specific product guidelines and the BNF for appropriate dosing regimens based on the condition being treated.

Mechanism of action

Flumethrin works by disrupting the normal functioning of the nervous system in insects. It acts on voltage-gated sodium channels, prolonging their activation and resulting in repetitive nerve firing. This leads to paralysis and eventual death of the target parasites. The compound mimics the action of natural pyrethrins, enhancing its insecticidal activity.

Pharmacodynamics

Flumethrin exhibits high insecticidal activity with a rapid onset of action against target pests. The compound's lipophilicity allows for effective penetration through the cuticle of arthropods, while its prolonged effects result in sustained activity against infestations. Flumethrin is generally safe for mammals when used according to recommended guidelines, with minimal toxicity observed in non-target species.

Pharmacokinetics

Flumethrin is well-absorbed through the skin and has a rapid distribution throughout body tissues. The compound is metabolized primarily in the liver, with metabolites excreted via urine and feces. The half-life of flumethrin can vary depending on the formulation and route of administration, but it tends to be relatively short, allowing for repeated applications as necessary.

Pregnancy

Flumethrin should only be used in pregnancy if the benefits outweigh the risks, as there is limited data on its safety in this population.

Breast-feeding

Caution is advised when using flumethrin during breastfeeding, as it is not known whether it is excreted in human milk.

Storage

Store in a cool, dry place, away from direct sunlight and out of reach of children.