GESTAVET PROST

Indications

• Induction of labor
• Termination of pregnancy
• Estrus synchronization
• Treatment of certain reproductive disorders in cattle

Dosage

Children: Paediatric dosing information is not available. Refer to the BNF for Children for any age-specific dosing recommendations.

Adults: Dosage may vary based on specific conditions and veterinary guidelines. Refer to the BNF for detailed dosing information.

Mechanism of action

Dcloprostenol acts as a potent agonist of the prostaglandin F2α receptor (FP), leading to various biological effects such as smooth muscle contraction, modulation of reproductive cycles, and stimulation of uterine contractions. Its action promotes luteolysis, resulting in decreased progesterone levels, thereby facilitating estrous synchronization and abortion in certain species.

Pharmacodynamics

Dcloprostenol exhibits its effects through the activation of the FP receptor, which is coupled to G-proteins. This leads to an increase in intracellular calcium levels and subsequent contraction of smooth muscle tissues, including the uterus. The drug's effects on the reproductive tract make it valuable in managing reproductive cycles and conditions associated with the estrous cycle in livestock.

Pharmacokinetics

After administration, dcloprostenol is rapidly absorbed and undergoes significant first-pass metabolism. Its bioavailability may vary based on the route of administration. The drug is primarily metabolized by the liver, with metabolites excreted in urine. The elimination half-life may vary, but it is generally short, requiring multiple doses for sustained effects.

Pregnancy

There are no adequate and well-controlled studies in pregnant women. Dcloprostenol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

Dcloprostenol is excreted in human breast milk. Caution should be exercised when administering to a nursing mother.

Storage

Store at room temperature, protected from light.

Formulations

• {'name': 'Dcloprostenol injection', 'strength': '5 mg/mL', 'form': 'solution for injection'}