BUDESONE 1OO INHALATION
BUDOSONIDE
What it does
Budesonide is a medication used to reduce inflammation in the body.
Commonly used for: asthma, chronic obstructive pulmonary disease (COPD), inflammatory bowel disease, allergic rhinitis
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
Ask about this medicine
Answers come only from this medicine's registration record, BNF monograph and interaction data - not medical advice.
Medicine sourcing is available in Kenya only. We don't sell or dispense medicines - licensed pharmacies do.
Sourcing - Kenya onlyRegistration & product details
Source: Food and Drugs Authority · fetched 2026-04-18 08:45:56 · updated 2026-10-20 04:00:14
About this medicine
Budesonide is a medication used to reduce inflammation in the body.
What it treats
- asthma
- chronic obstructive pulmonary disease (COPD)
- inflammatory bowel disease
- allergic rhinitis
How it works
Budesonide works by calming down the immune system's response, which helps to decrease swelling and irritation in the airways and intestines.
Who it's for
Budesonide is for people suffering from conditions like asthma, COPD, or inflammation in the gut.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: budosonide
Budesonide is a synthetic corticosteroid that exhibits anti-inflammatory effects. It is primarily used in the management of asthma and chronic obstructive pulmonary disease (COPD), as well as allergic rhinitis and other conditions requiring anti-inflammatory treatment. Budesonide works by reducing inflammation in the airways, leading to improved respiratory function and reduced symptoms.
Indications
- Asthma
- Chronic obstructive pulmonary disease (COPD)
- Allergic rhinitis
- Eosinophilic esophagitis
- Inflammatory bowel disease (IBD)
Dosage
Children: Refer to the BNF for Children for appropriate dosing.
Adults: Refer to the specific product information and local guidelines for appropriate dosing.
Mechanism of action
Budesonide binds to glucocorticoid receptors, which, upon activation, translocate to the nucleus and regulate the expression of anti-inflammatory proteins while inhibiting pro-inflammatory cytokines. This results in decreased inflammation and modulation of immune responses. Budesonide also inhibits the migration of leukocytes to sites of inflammation.
Pharmacodynamics
Budesonide has potent anti-inflammatory properties that help to control inflammation in the respiratory tract. The onset of action for budesonide is relatively quick, leading to symptomatic relief in asthma and COPD. Its effects can be long-lasting, allowing for improved lung function and reduced frequency of exacerbations.
Pharmacokinetics
Budesonide is administered via inhalation, allowing for direct delivery to the lungs. It undergoes extensive first-pass metabolism in the liver, which results in a low systemic bioavailability (approximately 10-15%). The drug is primarily metabolized by CYP3A4 enzymes, and its elimination half-life ranges from 2 to 3 hours. Budesonide is excreted mainly via urine as metabolites, with less than 1% excreted unchanged.
Contra-indications
- Hypersensitivity to budesonide or any of its components
- Untreated systemic infections
Adverse effects
- Headache
- Nausea
- Vomiting
- Dizziness
- Cough
- Throat irritation
- Oral candidiasis
- Adrenal suppression
- Growth retardation in children
Interactions
- CYP3A4 inhibitors may increase systemic exposure to budesonide
- Strong CYP3A4 inducers may decrease the efficacy of budesonide
Precautions
- Use with caution in patients with active or latent tuberculosis
- Monitor for signs of adrenal suppression, especially during stress
- Consider alternative treatments in patients with severe liver disease
Pregnancy
Budesonide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
Budesonide is excreted in breast milk; use caution and consider benefits versus risks.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Formulations
- Inhalation aerosol
- Nebulizer solution
- Nasal spray
- Oral extended-release capsule
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.