CLANZA S SOFT CAPSULES (Each capsule contains Accelotenac 100mg)
Accelotenac
What it does
Accelotenac is a medication used to relieve pain and reduce inflammation.
Commonly used for: pain relief, inflammation reduction
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Food and Drugs Authority · fetched 2026-05-22 02:34:50 · updated 2026-10-20 04:00:09
About this medicine
Accelotenac is a medication used to relieve pain and reduce inflammation.
What it treats
- pain relief
- inflammation reduction
How it works
It works by blocking substances in the body that cause pain and swelling.
Who it's for
It is suitable for adults and children who need help managing pain or inflammation.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: accelotenac
Accelotenac is a non-steroidal anti-inflammatory drug (NSAID) used primarily for the management of pain and inflammation. It is often indicated in conditions such as osteoarthritis, rheumatoid arthritis, and acute pain. Like other NSAIDs, it works by inhibiting the cyclooxygenase enzymes (COX-1 and COX-2), which play a key role in the synthesis of prostaglandins that mediate pain and inflammatory responses.
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Acute pain
- Musculoskeletal disorders
- Post-operative pain management
Dosage
Children: Refer to the BNF for Children for appropriate dosing in children based on age, weight, and the condition being treated.
Adults: Refer to the specific clinical guidelines or BNF for appropriate dosing based on the condition being treated.
Mechanism of action
Accelotenac exerts its therapeutic effects by inhibiting the activity of cyclooxygenase enzymes (COX-1 and COX-2), leading to a decrease in the production of prostaglandins. This results in reduced inflammation, analgesia, and antipyretic effects.
Pharmacodynamics
The pharmacodynamic effects of accelotenac are primarily due to its ability to reduce pain and inflammation. By lowering prostaglandin levels, it decreases the sensitivity of pain receptors and inhibits the inflammatory response. This NSAID provides symptomatic relief in various painful conditions, improving patient mobility and quality of life.
Pharmacokinetics
Accelotenac is well-absorbed after oral administration, with peak plasma concentrations typically occurring within 1 to 2 hours. It is extensively metabolized in the liver, primarily through conjugation, and has a relatively short half-life. The elimination of the drug occurs primarily through the kidneys. Dose adjustments may be necessary in patients with renal impairment.
Contra-indications
- Hypersensitivity to accelotenac or any component of the formulation
- Active peptic ulcer disease
- Severe heart failure
- History of gastrointestinal bleeding or perforation related to previous NSAID therapy
- Severe hepatic impairment
- Severe renal impairment
Adverse effects
- Gastrointestinal disturbances such as nausea, vomiting, and diarrhea
- Dyspepsia
- Abdominal pain
- Headache
- Dizziness
- Rash or pruritus
- Edema
- Increased blood pressure
- Renal toxicity including acute kidney injury
Interactions
- Increased risk of gastrointestinal bleeding when used with other NSAIDs or anticoagulants
- May reduce the antihypertensive effect of ACE inhibitors and diuretics
- Increased risk of nephrotoxicity with concurrent use of other nephrotoxic drugs
- May enhance the effects of anticoagulants like warfarin
Precautions
- Use with caution in patients with a history of cardiovascular disease
- Monitor renal function in patients with renal impairment or those on diuretics
- Assess for signs of gastrointestinal bleeding, especially in elderly patients
- Caution in patients with asthma, as NSAIDs may exacerbate symptoms
Pregnancy
Use during pregnancy, particularly in the third trimester, is not recommended due to potential risks to the fetus, including cardiovascular and renal issues.
Breast-feeding
Limited data is available; use with caution and assess risk-benefit.
Storage
Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
Formulations
- Oral tablets
- Topical gel
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.