What it does
Citocholine is a supplement that may help support brain health and cognitive function.
Commonly used for: Cognitive impairment, Memory problems, Stroke recovery
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Food and Drugs Authority · fetched 2026-04-18 08:37:14 · updated 2026-10-20 04:00:09
About this medicine
Citocholine is a supplement that may help support brain health and cognitive function.
What it treats
- Cognitive impairment
- Memory problems
- Stroke recovery
How it works
Citocholine is thought to support the production of important brain chemicals that help with thinking and memory.
Who it's for
Adults looking to improve brain function or recover from a stroke.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: citocholine
Citocholine, also known as citicoline or CDP-choline, is a naturally occurring compound in the body that plays a crucial role in the synthesis of phospholipids, particularly phosphatidylcholine, which is a major component of cell membranes. It is often used as a cognitive enhancer and neuroprotective agent due to its potential benefits in improving memory and cognitive functions. Citocholine is also being investigated for its role in the management of neurological disorders such as stroke and head trauma.
Indications
- Cognitive impairment
- Acute ischemic stroke
- Head trauma
- Neurodegenerative disorders
- Memory enhancement
Dosage
Children: Refer to pediatric dosing guidelines as specific doses may vary based on the child's condition and weight.
Adults: Refer to prescribing guidelines for specific dosing regimens as they may vary based on indication and clinical scenario.
Mechanism of action
Citocholine acts as a precursor to the neurotransmitter acetylcholine and stimulates the synthesis of phosphatidylcholine in neuronal membranes. This enhances membrane integrity and promotes neuronal repair. It also increases the levels of brain-derived neurotrophic factor (BDNF), which supports neuronal survival and function. Additionally, citocholine may improve cerebral blood flow and reduce the effects of ischemia.
Pharmacodynamics
The pharmacodynamic effects of citocholine are primarily related to its role in neurotransmitter synthesis and neuronal membrane integrity. By increasing the availability of acetylcholine, citocholine enhances cholinergic transmission, which is essential for cognitive processes such as learning and memory. It also exhibits neuroprotective properties, potentially reducing the extent of neuronal damage following ischemic events.
Pharmacokinetics
Citocholine is well-absorbed following oral administration, with peak plasma concentrations typically occurring within 1-2 hours. It is rapidly distributed throughout the body, crossing the blood-brain barrier effectively. The compound is metabolized in the liver and is eliminated primarily through renal excretion. The half-life of citocholine is approximately 3-5 hours, allowing for relatively frequent dosing in clinical settings.
Adverse effects
- Nausea
- Headache
- Diarrhea
- Abdominal pain
- Dizziness
Precautions
- Use with caution in patients with a history of gastrointestinal disorders
- Monitor for signs of hypersensitivity
- Caution in patients with renal impairment
Pregnancy
There is limited data on the use of citocholine during pregnancy. It should be used only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
Citocholine is excreted in breast milk. Caution should be exercised when administering to breastfeeding women.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
Formulations
- Tablet
- Injection
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.